In the present study, we propose a novel clustering-based method for modeling accurate fuzzy rule-based classification systems. The new method is a combination of a data mapping method, subtractive clustering method and an efficient gradient descent algorithm. A data mapping method considers the intricate geometric relationships that may exist among the data and computes a new representation of...

UNLABELLED A Genomic Target Database (GTD) has been developed having putative genomic drug targets for human bacterial pathogens. The selected pathogens are either drug resistant or vaccines are yet to be developed against them. The drug targets have been identified using subtractive genomics approaches and these are subsequently classified into Drug targets in pathogen specific unique metaboli...

-Studies of chemical ecology of an organism are founded on the isolation and identification of a semiochemical, often comprised of two or more synergistic compounds (each synergist alone has little activity, but presented together they are bioactive). Chromatographic fractionation and bioassay methods of binary splitting, additive combination, and subtractive combination are compared for effici...

Using PCR-select subtractive cDNA hybridization technique, 57 expressed sequence tags (ESTs) were isolated from 240 clones of a modified live Edwardsiella ictaluri vaccinated vs. sham-vaccinated channel catfish anterior kidney subtractive library. The transcription levels of the 57 ESTs in response to E. ictaluri vaccination were then evaluated by quantitative PCR (QPCR). Of the 57 ESTs, 43 wer...

A method to approximate derivatives of real functions using complex variables which avoids the subtractive cancellation errors inherent in the classical derivative approximations is described. Numerical examples illustrating the power of the approximation are presented.

The cloning of genes expressing proteins that are differentially expressed in the organ microvasculature has the potential to address a variety of problems ranging from the analysis of disease pathogenesis to drug targeting for particular tissues. This study describes a methodology designed to analyze differential protein expression in the brain microvasculature. The method can be applied to ot...

Discrepancies in the patterns of cortical activation across studies may be attributable, in part, to differences in baseline tasks, and hence, reflect the limits of the subtractive logic underlying much of neuroimaging. To assess the extent of these effects, three of the most commonly used baseline conditions (rest, tone monitoring, and passive listening) were compared using phoneme discriminat...

The reconceptualization of sex role classification to include psychological androgyny is presented. An explanation of this concept is followed by a summary of related research and a critique of instruments which purport to assess sex role orientation. The implications of the results of sex role research for athletics as well as future directions in such research are discussed. The discussion ce...