The title compound, C(15)H(21)N(3)O(3)S, is known to be an impurity of gliclazide [systematic name: N-(hexa-hydro-1H-cyclopenta[c]pyrrol-2-ylcarbamo-yl)-4-methyl-benzene-sulfonamide], a sul-fonyl-urea anti-diabetic drug. Gliclazide has a p-tolyl group substituting the sulfonamide functionality, while the title mol-ecule contains an o-tolyl group. Both five-membered fused rings adopt envelope co...

Five Bedsonia (Chlamydia) isolates from lymphogranuloma venereum (LGV) patients were tested for inclusion type, sulfonamide sensitivity, and mouse virulence. Two matched the classical description of LGV agents. Two were not virulent for mice by the intracerebral route, therefore fitting the description for trachoma-inclusion conjunctivitis agents. One was highly virulent for mice and sulfonamid...

Simple sulfonamide and amide derivatives of tris(2-aminoethyl)amine (Tren) are known to promote the translocation or flip-flop of phosphatidylcholine, but not phosphatidylserine, across bilayer membranes. This paper describes the synthesis of a 300-member, spatially encoded library of Tren derivatives with appended peptide--sulfonamide and peptide--urea arms. The library was synthesized using t...

Certain microbes can transform antibiotics in the environment. However, little is known about the identity of these microbes and their antibiotic biotransformation processes. The objectives of this study were to (1) isolate bacterial strains capable of transforming antibiotics, (2) determine the biotransformation kinetics of antibiotics, (3) characterize the effects of background carbons on the...

Bacteria which are sulfonamide-sensitive have been reported to be incapable of the rapid utilization of folic acid for inhibition reversal (Alimchandani and Sreenivasan, J. Bacteriol. 73:538, 1957; Krieg and Pelczar, J. Bacteriol. 80:242, 1960; Davis and Feingold, p. 343. In I. C. Gunsalus and R. Y. Stanier [ed.], The Bacteria, vol. 4, Academic Press, Inc., New York, 1962), presumably because o...

background marine sponge/nano-cuo as a natural catalyst efficiently catalyzed the sulfonylation reaction of p-chlorobenzene sulfonyl chlorides with amines in order to prepare sulfonamides. the advantages included use of a natural catalyst, ease of handling, requirement of a very small amount of catalyst, mild reaction condition and appropriateness to high yield. objectives the current study aim...

The design, synthesis, and catalytic application of a highly enantioselective and indefinitely stable polymer-supported Cinchona-based bifunctional sulfonamide is reported.

The diversity-oriented synthesis of bisindole derivatives to construct concise libraries using consecutive cross-coupling reactions and prepare new sulfonamide type fluorous protecting groups is presented.

A sulfonamide-based electrolyte can greatly improve the cycling stability of commercial LiCoO 2 cathode at high cut-off voltages in Li metal||LCO batteries by stabilizing electrode–electrolyte interfaces on both anode and cathode.