AMP-activated protein kinase (AMPK) plays a critical role in the stimulation of glucose transport in response to hypoxia and inhibition of oxidative phosphorylation. In the present study, we examined the signaling pathway(s) mediating the glucose transport response following activation of AMPK. Using mouse fibroblasts of AMPK wild type and AMPK knockout, we documented that the expression of AMP...

Magnesium batteries are promising candidates for post-lithium energy storage systems due to their low cost, high volumetric density, and risk of dendrite formation. This study reports a new magnesium ion conducting ionogel electrolyte based on Metal-Organic Framework (MOF) structure (UiO-66) impregnated with an ionic liquid, bis[(trifluoromethyl)sulfonyl]imide in 1-ethyl-3-methylimidazolium bis...

A new 3D Mn(II) coordination polymer, [Mn(2)(HCO(2))(L)(2)(N(3)) x MeOH](infinity) (1) (L = nicotinate N-oxide), was synthesized by a solvothermal reaction and characterized magnetically. Complex 1 is a typical antiferromagnet with alternating azide/azide/formate/formate bridges, exhibiting a new -J(1)J(1)J(2)J(2)- coupling sequence. This is the first complex to contain an azide, formate and an...

The title compound, [Zn(C(6)H(4)NO(3))(N(3))], has been prepared by the reaction of nicotinate N-oxide acid, zinc(II) nitrate and sodium azide. The Zn atom is five coordinated by two azide anions and three nicotinate N-oxide ligands. Each nicotinate N-oxide bridges three Zn atoms, whereas the azide bridges two Zn atoms, resulting in the formation of a two-dimensional metal-organic polymer devel...

This work represents our initial effort in identifying azide/alkyne pairs for optimal reactivity in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. In previous works, we have identified chelating azides, in particular 2-picolyl azide, as "privileged" azide substrates with high CuAAC reactivity. In the current work, two types of alkynes are shown to undergo rapid CuAAC reactions u...

The respiration of T. cruzi epimastigotes was studied using KCN (1 mM) and NaN3 (5 mM) as inhibitors and glucose (33 mM) as substrate. NaN3 inhibits 18% and KCN 58% of the oxygen uptake when T. cruzi cultures enter the stationary phase. The azide-inhibition pattern closely follows endogenous respiration pattern throughout the different growth phases. Titration of the oxygen uptake with cyanide ...

The effect of adding azide to photosystem II (PS II) membrane samples (BBY preparation), with or without chloride, has been investigated using continuous wave (CW) and pulsed EPR spectroscopy. In the BBY samples with 25 mM chloride, we observed that the inhibition induced by azide is partly recovered by the addition of bicarbonate. Electron spin-echo envelope modulation (ESEEM) was used to sear...