Introduction Although co-trimoxazole ('Septrin', 'Bactrim') is in common use, the incidence of associated erythropoietic disturbance is low. This is surprising, since the trimethoprim component has been shown to have some action on human dihydrofolate reductase (Hitchings, 1969) and the sulphamethoxazole might be expected to cause haematological complications as do other sulphonamides (Laurence...

RESEARCH ARTICLE Design, Synthesis and Evaluation of Substituted 3-(1, 4-Diazepanyl)Methyl-Phenyl-Sulphonamides as Potent 5-HT6 Antagonists in Cognitive Disorders V.S. Velingkar, A.K. Chindhe, Mrunal Sanaye and Madhumangiri Gatane Department of Pharmaceutical Chemistry, Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, Mumbai, India Department of Pharmaceutical Chemistry & ...

A group of strains of Staphylococcus albus is described which produced neither coagulase nor haemolysin, was slightly sensitive or resistant to novobiocin, and sensitive to all other antibiotics, to sulphonamides, and to nitrofurantoin. The agglutinating antigen 51 was isolated from all strains from patients with urinary infections and abundant pyuria. In more than 40 cases studied it was not p...

The antimicrobial era began in 1910 with the introduction of Salvarsan into the therapy of syphilis and expanded in the 1930s when the first chemotherapeuticals (sulphonamides) made their way into clinical use in human medicine. The antibiotic, penicillin, was discovered by Alexander Fleming (Fleming, 1929) but was not introduced for therapy until 1941. Shortly after its introduction for use in...

A male aged 54 years presented with a pathological fracture of the right femur at the subtrochanteric level. The fracture site showed a lytic lesion with expansion of the bone, considered to be a metastasis. On histology, however, the area turned out to be malakoplakia of bone. The patient responded well to antibiotics and sulphonamides along with skeletal traction. This appears to be the fourt...

When prevalence of meningococcal disease is increased contacts of cases may require chemoprophylaxis, and sodium sulphadiazine is the drug of choice. However, increasing numbers of meningococci are resistant to sulphonamides (Fallon, 1975, 1977) andmany alternative chemoprophylactic agents are ineffectual. Sodium fusidate is active against a few strains of meningococci in vitro (Barber and Wate...