Recently, several novel approaches to the treatment of migraine have been advanced, including selective 5-hydroxytryptamine (or serotonin) 1B/1D (5-HT(1B/1D)) receptor agonists such as sumatriptan and 5-HT(1F) receptor agonists such as LY344864. Many 5-HT(1B/1D) receptor agonists have been identified based on their ability to produce cerebral vascular contraction, whereas LY344864 was identifie...

Background—During the interdigestive state in humans, erythromycin 40 mg induces a premature activity front that starts in the stomach, while erythromycin 200 mg induces a prolonged period of enhanced antral contractile activity. Aims—To study the involvement of a cholinergic pathway in themotor eVects of erythromycin using the muscarinic antagonist atropine and the neural 5-HT1 receptor agonis...

BACKGROUND The antimigraine drugs ergotamine and sumatriptan may cause angina-like symptoms, possibly resulting from coronary artery constriction. We compared the coronary vasoconstrictor potential of a number of current and prospective antimigraine drugs (ergotamine, dihydroergotamine, methysergide and its metabolite methylergometrine, sumatriptan, naratriptan, zolmitriptan, rizatriptan, avitr...

BACKGROUND Migraine pain relief is reported by more than 50% of patients who receive low dose (3 mg) of sumatriptan. Currently, there is no two-step autoinjector of low-dose sumatriptan available on the market for acute migraine treatment. To fulfill this need, a fully assembled, single-dose, subcutaneous autoinjector (sumatriptan 3 mg; product-code DFN-11) was developed. The device allows for ...

OBJECTIVE To determine whether acute migraine treatment outcome is different in migraine with aura compared with migraine without aura. METHODS We examined pooled outcome data for sumatriptan treatment of migraine with and without aura from the sumatriptan/naratriptan aggregate patient database. We also examined similar outcome data for inhaled dihydroergotamine (DHE) from a single, large ran...

25 Serotonin (5-HT) modulates pain and anxiety from within the midbrain periaqueductal grey (PAG). In the 26 present study, the effects of 5-HT and 5-HT1/2 subtype selective ligands on rat PAG neurons were 27 examined using whole-cell patch-clamp recordings in brain slices. In voltage clamp, 5-HT produced 28 outward and inward currents in distinct subpopulations of neurons which varied througho...

The aim of the present study was to determine whether donitriptan and sumatriptan decreased jugular venous oxygen saturation and increased carbon dioxide partial pressure in venous blood. However, previous studies conducted with these compounds cannot discriminate whether the decrease of venous oxygen saturation is dependent of cranial vasoconstrictor. In the present study, vehicle (n = 10), do...

The present investigation deals with the formulation of oral dissolving films (ODFs) of sumatriptan succinate which is used for the treatment of migraine. Rapidly dissolving films have acquired great importance in present scenario because of exclusive properties. The films of sumatriptan succinate were carried out using different grades of HPMC E3, E6, and E15, maltodextrin DE6, xanthan gum and...

Chan KY, Labruijere S, de Vries R, Danser AHJ, Villalón CM, MaassenVanDen Brink A. Cranioselectivity of sumatriptan revisited. J. Headache Pain, 2010 oct; 11 Suppl.1):203 Labruijere S, Chan KY, van Houten ELAF, de Vries R, Kramer P, Danser AHJ, Villalón CM, Visser JA, MaassenVanDen Brink A. The effect of DHT on vascular reactivity. J. Headache Pain, 2010 oct; 11 Suppl.1):201 Labruijere S, Chan ...