The phenomenon of chimerism is reviewed against an understanding of adaptive immunity in vertebrates. It is shown that chimerism can be regarded as a ubiquitous condition and this suggests that monophylesis has played little part in evolution. It is suggested that the adaptive immune response has a special role in facilitating the development of chimerism and that the consensus view of adaptive...

pathogenic infection in tasar silkworm, antheraea mylitta drury. is common and there is a breed specific response regarding tolerance. observations reveal the possibility of differential response by haemocytes to microbial infection in different breeds. hence, the susceptibility of three eco-races of tasar silkworm viz. daba, sarihan and raily to antheraea mylitta cytoplasmic polyhedrosis virus...

Background: Drug resistance is widely believed to be an increasingly serious threat to global public health. We have previously reported that short term exposure of microorganisms to diagnostic ultrasound waves could significantly alter their sensitivity to antibiotics. In our previous studies, Klebsiella pneumoniae showed major differences in the sensitivity to antibiotics in exposed and non-e...

PURPOSE To analyze treatment outcomes for nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) at a single institution. PATIENTS AND METHODS Patients with newly diagnosed NLPHL between 1996 and 2013 were reviewed retrospectively. Patients treated before 1996 were excluded because the majority received extended field radiation therapy (RT) alone. RESULTS Fifty-five patients (22 ≤ 21 years...

Purpose: Lymphocytic infiltration of tumors predicts improved survival in patients with breast cancer. Previous studies have suggested that this survival benefit is confined predominantly to the basal-like subtype. Immune infiltration in ovarian tumors is also associated with improved prognosis. Currently, it is unclear what aspects of the immune response mediate this improved outcome. Experime...

background: the aim of this study was to investigate the efficacy and safety of metronomic capecitabine chemotherapy in pretreated elderly patients with advanced gastric carsonoma. patients and methods: eligible patients were treated with capecitabine at a fixed dose of 1000mg daily until disease progression or toxicity. endpoints were overall response rate, safety, progression-free survival an...

Human survival has relied upon the ability to withstand starvation through energy storage, the capacity to fight off infection by a proinflammatory immune response, and the ability to cope with physical stressors by an adaptive stress response. Energy storage, mainly as glycogen in liver and triglycerides in adipose tissue, is regulated by the anabolic actions of insulin. On the other hand, mob...

Variable, diversity and joining (V(D)J) recombination and immunoglobulin class switch recombination (CSR) are key processes in adaptive immune responses that naturally generate DNA double-strand breaks (DSBs) and trigger a DNA repair response. It is unclear whether this response is associated with distinct survival signals that protect T and B cells. Glycogen synthase kinase 3β (GSK3β) is a con...

atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by innate and adaptive immune responses to a variety of microbial and self-antigens. given the crucial role of adaptive immunity in the pathogenesis of atherosclerosis, this study was performed to investigate the proliferative response of peripheral blood mononuclear cells (pbmc) and interleukin (il)-2 producti...

model predictive controller is widely used in industrial plants. uncertainty is one of the critical issues in real systems. in this paper, the direct adaptive simplified model predictive control (smpc) is proposed for unknown or time varying plants with uncertainties. by estimating the plant step response in each sample, the controller is designed and the controller coefficients are directly ca...