نتایج جستجو برای: sustained release matrix tablet

تعداد نتایج: 665237  

Journal: :pharmaceutical and biomedical research 0
vijay sharma department of pharmaceutics, rajiv academy for pharmacy, n.h. #2, delhi – mathura road, p.o. chattikara, mathura, uttar pradesh – 281001, india kamla pathak department of pharmaceutics, pharmacy college saifai, uprims&r, saifai, etawah, uttar pradesh, india

it has been observed that most of the chemical entities have high lipophilicity and poor aqueous solubility, which result in poor bioavailability. in order to improve the bioavailability, the release behavior of such drugs should be improved. although there are numerous techniques to handle solubility related issue, but they are expensive due to involvement of complicated equipments, advanced m...

Journal: :research in pharmaceutical sciences 0

terbutaline sulfate exhibits extensive first pass metabolism and a short elimination half life which makes frequent oral administration of the drug inevitable. a novel buccoadhesive controlled delivery system of the drug can easily overcome the problem. a two-layered core tablet composed of a fast release layer made of mannitol, lactose, peg and the drug attached to a sustained release layer co...

2013
Ishab Kumar Gali Vidyasagar Anil Bhandari Nishant Upadhyay

Floating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. The tablets were formulated by using central composite design having two independent variables at three levels. ...

Journal: :The Ulster Medical Journal 1961
David R. Hadden Conn Lucey

DIETHYLPROPION ("Tenuate") has been shown to be useful in the treatment of refractory obesity (Seaton et al., 1961). Appetite suppression with the standard preparation is reported to last about four hours (Spielman, 1959) and the drug must be taken at least three times daily. This paper reports the use of a longacting preparation of the drug, which need be taken only once a day. It is marketed ...

Journal: :The Medical journal of Malaysia 2004
E Magosso K H Yuen W P Choy S S N Ling B H Ng N Ur-Rahman J W Wong

The bioavailability of a generic diclofenac sodium sustained release tablet preparation (Zolterol, SR) was compared with the innovator product, Voltaren, SR. Twelve healthy adult male volunteers participated in the study, which was conducted according to a randomized, two-way crossover design with a wash out period of one week. The bioavailability of diclofenac was compared using the parameters...

2016
Dominique J. Dubois

[This retracts the article on p. 137 in vol. 5, PMID: 24966835.].

Journal: :Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007
Uttam Mandal Veeran Gowda Animesh Ghosh Senthamil Selvan Sam Solomon Tapan Kumar Pal

The aim of the current study was to design an oral sustained release matrix tablet of metformin HCl and to optimize the drug release profile using response surface methodology. Tablets were prepared by non-aqueous wet granulation method using HPMC K 15M as matrix forming polymer. A central composite design for 2 factors at 3 levels each was employed to systematically optimize drug release profi...

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