Purpose: The aim of this work was to prepare nimodipine-loaded alginate-chitosan beads for sustained drug release. Methods: Nimodipine-loaded alginate-chitosan beads were prepared by ionic gelation method using various combinations of chitosan and Ca 2+ as cations and alginate as anion. The swelling ability and in vitro drug release characteristics of the beads were studied at pH 1.2 and 6.8. I...

The dual release system is used to achieve both quick and sustained release effect from dosage form. The dual release action achieve by using core compressed tablet, bi-layer or multi layer tablet, IR and SR granules containing matrix tablet and capsules. Some researcher formulated dual release system by incorporating disintegrants for immediate release part and different polymers for sustained...

Introduction Wound pH influences residence time and activity of growth factors in healing [1]. Hence, pH responsive sustained release growth factor delivery system capable of modulating release pattern in response to varying wound pH is beneficial for treatment of wound. Thus, potential of poly (N-iso propylacrylamide-co-acrylic acid) hydrogel as pH sensitive sustained release system for wound ...

Now a days as very few drugs are coming out of research and development and already existing drugs are suffering the problem of resistance due to their irrational use specifically in case of drugs like antibiotics. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery.

The aim of the present work is to prepare and evaluate the oral mucoadhesive sustained release nanoparticles of clarithromycin in order to improve patient compliance by simplifing its administration, improving its therapeutic effect and reducing its dose related side effect. Clarithromycin containing gliadin nanoparticles were prepared by desolvation method using pluronic F-68 as a stabilizing ...