نتایج جستجو برای: svz
تعداد نتایج: 1022 فیلتر نتایج به سال:
Isocitrate dehydrogenase 1 mutations drive human gliomagenesis, probably through neomorphic enzyme activity that produces D-2-hydroxyglutarate. To model this disease, we conditionally expressed Idh1R132H in the subventricular zone (SVZ) of the adult mouse brain. The mice developed hydrocephalus and grossly dilated lateral ventricles, with accumulation of 2-hydroxyglutarate and reduced α-ketoglu...
are incurable diseases characterised by high inter-and intra-tumor heterogeneity (ITH), diffuse brain infiltration and treatment resistance. Over the last fifteen years, studies at the interface between stem cell biology and cancer research have established the existence of cancer stem-like populations in GBM and other brain tumors (reviewed in [1]). These data have been accompanied by speculat...
Coordinated regulation of neuronal progenitor differentiation in the subventricular zone (SVZ) is a fundamental feature of adult neurogenesis. However, the molecular control of this process remains mostly undeciphered. Here, we investigate the role of neuregulins (NRGs) in this process and show that a NRG receptor, ErbB4, is primarily expressed by polysialylated neural cell adhesion molecule im...
We propose an integral three-dimensional (3D) display system with a wide viewing zone and depth range using time-division eye-tracking technology. In the proposed system, optical (OVZ) is narrowed to size that only covers eye increase light ray density lens array long focal length. addition, low crosstalk respect viewer’s movement constructed by forming combined OVZ (COVZ) both eyes through dis...
Abstract Glioblastoma (GBM) is the most common and aggressive primary brain cancer in adults. Although multiple oncogenic mutations have been identified neural stem cells of subventricular zone (SVZ) humans, dynamic process how tumor initiation begins with a mutation-harboring remains elusive. To better understand GBM evolves, we analyzed longitudinal transcriptomic changes using spontaneous, s...
Abstract Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we capture characterize in vitro primed quiescent identify LRIG1 an important regulator. We show that BMP-4 signaling induces dormant non-cycling state (d-qNSCs), whereas combined BMP-4/FGF-2 distinct poised for c...
The adult subventricular zone (SVZ) contains Nestin+ progenitors that differentiate mainly into neuroblasts. Our previous data showed that interleukin-10 (IL-10) regulates SVZ adult neurogenesis by up-regulating the expression of pro-neural genes and modulating cell cycle exit. Here we addressed the specific mechanism through which IL-10 carries out its signaling on SVZ progenitors. We found th...
Adult mouse subventricular zone (SVZ) neural stem/progenitor cells are multipotent self-renewing cells that retain the capacity to generate the major cell types of the central nervous system in vitro and in vivo. The relative ease of expanding SVZ cells in culture as neurospheres makes them an ideal model for carrying out large-scale screening to identify compounds that regulate neural progenit...
Remyelination involves the generation of new myelin sheaths around axons, as occurs spontaneously in many multiple sclerosis (MS) lesions and other demyelinating diseases. When considering repairing a diseased brain, the adult mouse subventricular zone (SVZ) is of particular interest since the stem cells in this area can migrate and differentiate into the three major cell types in the central n...
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