Background and objectives: Centaurea bruguierana subsp. belangeriana (DC.) Bornm. is an annual herb widely distributed in the world. It is used in folk medicine of Iran as an anti-ulcer for gastrointestinal problems. Previous studies have revealed the anti-ulcer effects of the plant extract and in the present study the anti-Helicobacter p...

UNLABELLED The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (CRISPR/Cas) system is an adaptive immune system present in many archaea and bacteria. CRISPR/Cas systems are incredibly diverse, and there is increasing evidence of CRISPR/Cas systems playing a role in cellular functions distinct from phage immunity. Previously, our laboratory reported one such a...

Aim Swarming motility is a virulence factor for Proteus mirabilis and coordinated multicellular movement of bacteria. In this study, we investigated the inhibitory effect hyperthermia on bacterial swarming antimicrobial resistance.Methods Thirty-one P. isolates were included in study. Seven inoculated agar plates incubated inside incubators with increasing temperature levels: at 36 °C (control)...

Pseudomonas aeruginosa is an opportunistic pathogen that orchestrate its disease manifestation via a complex communication system known as quorum sensing (QS). Under the regulation of this network QS system, myriad virulence factors including flagella and pili contribute to motility. To establish infection in host, P. must first attach itself host cells with assistance it would be mere impossib...

Pseudomonas aeruginosa possesses complex regulatory networks controlling virulence and survival under adverse conditions, including antibiotic pressure, which are interconnected and share common regulatory proteins. Here, we screen a panel of 13 mutants defective in intracellular proteases and demonstrate that, in addition to the known alterations in Lon and AsrA mutants, mutation of three prot...

The TorD family of specific chaperones is divided into four subfamilies dedicated to molybdoenzyme biogenesis and a fifth one, exemplified by YcdY of Escherichia coli, for which no defined partner has been identified so far. We propose that YcdY is the chaperone of YcdX, a zinc protein involved in the swarming motility process of E. coli, since YcdY interacts with YcdX and increases its activit...

Bacteriophage infection has profound effects on bacterial biology. Clustered regular interspaced short palindromic repeats (CRISPRs) and cas (CRISPR-associated) genes are found in most archaea and many bacteria and have been reported to play a role in resistance to bacteriophage infection. We observed that lysogenic infection of Pseudomonas aeruginosa PA14 with bacteriophage DMS3 inhibits biofi...

Swarming of Pseudomonas aeruginosa is a complex adaptation leading to increased 1 production of virulence factors and antibiotic resistance 2 3 4 5 6 Joerg Overhage*, Manjeet Bains, Michelle D. Brazas, and Robert E. W. Hancock 7 8 Centre for Microbial Diseases & Immunity Research, University of British Columbia, 2259 9 Lower Mall, Vancouver BC, Canada 10 11 12 Running title: Pseudomonas swarmin...

Bacillus thuringiensis is being used worldwide as a biopesticide, although increasing evidence suggests that it is emerging as an opportunistic human pathogen. While phospholipases, hemolysins, and enterotoxins are claimed to be responsible for B. thuringiensis virulence, there is no direct evidence to indicate that the flagellum-driven motility plays a role in parasite-host interactions. This ...