The tumor suppressor p53 can be sent to the proteasome for degradation by placing its nucleo-cytoplasmic shuttling under ligand control. Endogenous p53 is ubiquitinated by MDM2 in the nucleus, and controlling the access of p53 to the nuclear compartment regulates its ubiquitination and proteasomal degradation. This was accomplished by the use of a protein switch that places nuclear translocatio...

in order to implement an integrated optical quantum circuit, designing waveguides based on the quantum box is of prime importance. to do this we have investigated optical waveguide both with and without optical pumping. the rate of absorption and emission using an array of algaas/gaas quantum box core/shell structure in the optical waveguide with various pumping intensities has computed. by con...

conclusions our results indicated that the dissemination of pi-1 was widespread in s. pneumoniae isolates, although no pi-2 isolates were detected. furthermore, the frequency of rlra and rrgc of clinical isolates was significantly more than that of normal flora isolates. results the results confirmed the presence of rlra and rrgc genes in both clinical (n = 39) and normal flora (n = 26) isolate...

drug design is generally achieved through trial and error methods, which is a time and resource consuming process and novel methods are needed to improve it. mathematical modelling is one of the possible solutions to speed up this process. in this study, we have presented box-jenkins model, to predict the vasorelaxant activity (pec50) of a set of benzopyrane compounds. we used the hyperchem sof...

grape is used in large amounts and different types (fresh, raisin, vinegar, molasses, juice, unriped grape and etc). remarkable amount also are preserved in stores and cold-rooms to be supplied out of season, that causes  quality and weight decrease. this research was conducted to study different factors which affect the grape shelf-life. obtaining more information about optimum conditions and ...

In this paper the parametric study is carried out to investigate the effect of number of cells in optimal cost of the non-prismatic reinforced concrete (RC) box girder bridges. The variables are geometry of cross section, tapered length, concrete strength and reinforcement of the box girders and slabs that are obtained using ECBO metaheuristic algorithm. The design is based on AASHTO standard s...

The Simplex Architecture is a runtime assurance framework where control authority may switch from an unverified and potentially unsafe advanced controller to backup baseline in order maintain the safety of autonomous cyber-physical system. In this work, we show that checks can replace requirement statically verify controller. This important as there are many powerful techniques, such model-pred...