s related to the PhD thesis I. Párdutz Á, Vécsei L, Schoenen J Systemic nitroglycerin administration increases nitric oxide synthase-immunoreactive cells in rat spinal trigeminal nucleus: towards a better understanding of the possible role of nitric oxide in migraine? Headache World, London, UK, 2000, Cephalalgia 20: 281. II. Párdutz Á,Vécsei L, Schoenen J Systemic nitroglycerin administration ...

the mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. to examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit. cerebral blood flow was measured by laser doppler flow-meter in 18 nzw rabbits anesthetized with sodium pentobarbital.  tetrodetoxin...

OBJECTIVES To determine whether transtympanic steroid administration may be an effective treatment for sudden onset sensorineural hearing loss (SSNHL) in patients for whom systemic steroid treatment has failed or who were not candidates for systemic steroids. METHODS The standard medical regimen for SSNHL usually involves systemic steroid therapy. Unfortunately, some patients do not respond s...

The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be useful for slowing down pulmonary fibrosis by biological activity other than antibacterial activity.

Atopic dermatitis (AD) is a chronic inflammatory disease characterized by the impairment of the skin-barrier function, increased oxidative cellular stress, and bacterial colonization. Hence, medical therapies of AD aim to control infection, reduce inflammation, and restore skin-barrier function by use of topical and systemic antibacterial drugs, topical corticosteroids, topical calcineurin inhi...

BACKGROUND Chronic administration of morphine cause physical dependence but the exact mechanism of this phenomenon remains unclear. The aim of this study is the assessment of systemic and intracerebroventricular (icv) administration of ramelteon (a melatonin receptor agonist) on morphine physical dependence. METHODS 88 adult male rats were divided into 2 major groups, namely "systematic" and ...

Blood and dialysate concentrations of fosfomycin were determined after intravenous and intraperitoneal application of 4 mg/liter in patients undergoing automated peritoneal dialysis. Maximum serum concentrations after intravenous (287.75 ± 86.34 mg/liter) and intraperitoneal (205.78 ± 66.78 mg/liter) administration were comparable. Ratios of intraperitoneal to systemic exposure were 1.12 (intra...

A routine aerobic culture of purulent material from a draining sinus tract of a patient with chronic lymphadenitis yielded growth of a fastidious gram-negative coccobacillus later identified as Brucella suis biotype 1. The patient responded to administration of antibacterial drugs and surgical drainage.

Infections caused by antibiotic-resistant bacteria, especially the "ESKAPE" pathogens, continue to increase in frequency and cause significant morbidity and mortality. New antimicrobial agents are greatly needed to treat infections caused by gram-negative bacilli (GNB) resistant to currently available agents. The Infectious Diseases Society of America (IDSA) continues to propose legislative, re...

objective: sulfur mustard (sm) is a potent mutagenic agent that targets several organs, particularly lung tissue. changes in morphological structure of the airway system are associated with chronic obstructive pulmonary deficiency following exposure to sm. although numerous studies have demonstrated pathological effects of sm on respiratory organs, unfortunately there is no effective treatment ...