Homoalanosine having a herbicidal activity was isolated from the culture filtrate of a soil isolate SC-1688 which was classified as Streptomyces galilaeus. The chemical structure of homoalanosine was determined to be L-2-amino-4-nitrosohydroxyaminobutyric acid by analyses of spectral and biological data. The antibiotic has high herbicidal activity at low concentrations against especially common...

For several years, photodynamic therapy (PDT) has been a treatment option for skin conditions such as nonmelanoma skin cancer. Recently, this technique has been studied for skin infections, particularly those in which biofilms have formed. The antibacterial, immunoregulatory, and regenerative effect of PDT may enable healing of antibioticresistant infections and infections at sites with limited...

Purulent diseases in otorhinolaryngology are of great interest due to their widespread prevalence and the objective difficulties treatment. One most frequently encountered nosological forms is purulent sinusitis. A key element complex treatment bacterial sinusitis systemic antibiotic therapy aimed at eradication pathobionts from focus infection. However, increasing worldwide drug resistance eti...

Abstract The development of antibacterial coatings is a promising approach to preventing biofilm formation and reducing the overuse systemic antibiotics. However, widespread antibiotic use has resulted in antibiotic‐resistant bacteria, limiting efficacy antibiotic‐based coatings. Herein, an coating developed by layer‐by‐layer (LbL) assembly two polymers namely PDLG (poly (D,L‐lactide‐co‐glycoli...

We report a kidney transplant recipient with severe skin- and soft-tissue infection mimicking necrotising fasciitis. Patient failed to respond to empirical antibiotic therapy for presumed bacterial cellulitis. Culture of aspirate from the wound and tissue samples revealed Cryptococcus neoformans. No signs of systemic cryptococcal infection were found. After antifungal treatment and surgical int...

The treatment of spleen abscess consists ofappropriate systemic antibiotic and removal of pus by percutaneous catheter, splenotomy or splenectomy.3'5 E. corrodens is usually susceptible to a broad-spectrum antibiotic such as ampicillin, cephalosporins, fluoroquinolones and thienamycins.''4 Finally, we choose radiographically guided percutaneous drainage for two reasons: the peripheral location ...

BACKGROUND To describe the utilisation of antibiotics in children and adolescents across 5 European countries based on the same drug utilisation measures and age groups. Special attention was given to age-group-specific distributions of antibiotic subgroups, since comparison in this regard between countries is lacking so far. METHODS Outpatient paediatric prescriptions of systemic antibiotics...

OBJECTIVES Analysing how systemic antibiotic agents were dispensed to outpatients in a Colombian population between January 2005 and December 2006 and assessing their economic cost as antibiotic use and abuse have been related to serious bacterial resistance. METHODS This was a descriptive observational study of antibiotic drug use; a database was compiled from medication usage records mainta...

Antibiotic usage promotes intestinal colonization of antibiotic-resistant bacteria. However, whether resistant bacteria gain dominance in enteric microflora or disseminate to extraintestinal viscera remains unclear. Our aim was to investigate temporal diversity changes in microbiota and transepithelial routes of bacterial translocation after antibiotic-resistant enterobacterial colonization. Mi...