PURPOSE To determine the consequences of the chronic use of systemic corticosteroids in children with juvenile rheumatoid arthritis by means of evaluating osteochondral effects depicted by magnetic resonance imaging. PATIENTS AND METHODS We reviewed clinical and magnetic resonance imaging findings in 69 children (72 knees) with juvenile rheumatoid arthritis. Two groups were studied. Group I: ...

delay the diagnosis and treatment [2, 3, 9]. The audiovestibular prognosis depends on steroid treatment within the first month of the symptoms [3], but hearing loss may progress to profound bilateral deafness if the patient has repeated attacks [3–5]. Our patient’s initial ocular symptoms occurred 4 yrs before her hearing loss. This was the clue leading to diagnosis and appropriate treatment wi...

STUDY OBJECTIVE The variable effectiveness of clinical asthma pathways to reduce hospital admissions may be explained in part by the timing of systemic corticosteroid administration. We examine the effect of early (within 60 minutes [SD 15 minutes] of triage) versus delayed (>75 minutes) administration of systemic corticosteroids on health outcomes. METHODS We conducted a prospective observat...

BACKGROUND Drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) represent contrasting poles of severe drug eruptions, and sequential reactivations of several herpesviruses have exclusively been demonstrated in the former. No previous studies, however, were extended beyond the acu...

Background – It is well known that for systemically administered drugs, such as corticosteroids, the therapeutic index cannot be improved by increasing their potency, since efficacy and safety are both attributable to circulating drug concentrations, and common receptor interactions. However, the validity of this assumption has not yet been investigated for inhaled corticosteroids, which are us...

Ayurveda, the science of life considers jwara (fever) as a separate disease. But in modern medicine, they consider it symptom an infection or ongoing pathology. Acharya Charaka introduces ailment causing DehaIndriya-Manas-Santapa

INTRODUCTION The fraction of exhaled nitric oxide (FeNO) and blood eosinophils, markers of local and systemic eosinophilic inflammation, respectively, are increased in asthmatic patients. Little is known concerning the relationship between the FeNO levels and blood eosinophils in asthmatics. METHODS Twenty severe asthmatics with persistent FeNO elevation (≥40 ppb) and blood eosinophilia (≥3%)...