Background and aim: Antimonial compounds are regarded as the treatment of choice for cutaneous leishmaniasis (CL). Systemic administration of these drugs have some side effects such as cardiotoxicity. The objective of this study was to evaluate the electrocardiographic (ECG) changes in patients with CL treated with systemic Glucantime.Materials and methods: This study w...

tricho-dento-osseous syndrome is a rare autosomal dominant disorder. immunosuppressive drugs, though critical to the treatment, have undesirable effects on patient's healing process. this is a case report of a 10-year-old female, suffering from tricho-dento-osseous syndrome who was under treatment with penicillamine. as the dental treatment was sought too late, both central and lateral incisors...

For the non-clinical safety evaluation of pharmaceuticals for new drug applications (NDA), various toxicity studies must be conducted at each stage, from clinical trials to NDA. topically applied drugs, level exposure administration site is high because administered directly site. However, systemic ophthalmic drugs generally lower than that effects may not adequately assessed. The bone marrow a...

Whereas the early phase of drug development for systemically acting drugs is mostly driven by the presumed relationship between safety/efficacy and concentration of drug in the systemic circulation, this relationship does not exist for topically applied drugs intended for local or regional action. For these topical drugs, systemic absorption is not desired and systemic exposure can often be kep...

Correspondence: Wilbert S Aronow Cardiology Division, New York Medical College, Macy Pavilion, Room 138, Valhalla, NY 10595, USA Tel +1 914 493 5311 Fax +1 914 235 6274 Email [email protected] Abstract: Systemic hypertension and chronic obstructive pulmonary disease (COPD) frequently coexist in the same patient, especially in the elderly. Today, a wide variety of antihypertensive drugs with diff...

Systemic hypertension and chronic obstructive pulmonary disease (COPD) frequently coexist in the same patient, especially in the elderly. Today, a wide variety of antihypertensive drugs with different mechanisms of action are available to the prescribing physician. In addition, combination drugs for hypertension are becoming increasingly popular. Certain antihypertensive drugs can affect pulmon...

Infectious lung diseases are inflammatory of the lungs caused by infectious agents such as bacteria, viruses or fungi. Oral intravenous administration antibiotics is most common method treatment, but some drugs have poor release stability, high systemic toxicity and susceptibility to drug resistance. Nanodrug delivery systems promising alternatives for treatment diseases, because they provide a...

Background and aim: Complications and resistance to pentavalent antimonial agents in cutaneous leishmaniasis, exhibit the need for effective alternative drugs. The aim of this study was to compare the efficacy of oral azithromycin with systemic meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis. Materials and Methods: Forty-seven patients with cutaneous leishmaniasis...

Hypersensitivity to anticonvulsant drugs have been reported many times. But anticonvulsant hypersensitivity syndrome (AHS) is a potentially fatal drug reaction with cutaneous and systemic reaction to the arene oxide-producing anticonvulsants, phenytoin, carbamazepine, and Phenobarbital sodium. The hall-mark features of this syndrome are: Fever, rash and lymphadenopathy. The epoxide hydrolase en...