Site-directed spin labeling EPR (SDSL-EPR) was used to determine the structure of the inhibitory region of TnI in the intact cardiac troponin ternary complex. Maeda and collaborators have modeled the inhibitory region of TnI (skeletal 96-112: the structural motif that communicates the Ca(2+) signal to actin) as a kinked alpha-helix [Vassylyev, D., Takeda, S., Wakatsuki, S., Maeda, K. & Maeda, Y...

Disclosure: Prof Kimby is on advisory boards for Celgene, Pharmacyclics, Janssen, Baxalta, Gilead, and AbbVie and has received research support from Roche and Pfizer. Prof Lenz: Gilead (advisory board, invited speaker), Janssen (advisory board, invited speaker, grant support), Celgene (advisory board, invited speaker, grant support), Roche (advisory board, invited speaker), NanoString (advisory...

By assaying the binding of wild-type Cro to a set of 40 mutant lambda operators in vivo, we have determined that the 14 outermost base pairs of the 17 base pair, consensus lambda operator are critical for Cro binding. Cro protein recognizes 4 base pairs in a lambda operator half-site in different ways than cI repressor. The sequence determinants of Cro binding at these critical positions in viv...

FOR AN e+e TeV LINEAR COLLIDER T. Tauchi, K. Fujii, S. Kawabata, T. Matsui, S. Takeda, M. Yoshioka, K. Yokoya KEK, National Laboratory for High Energy Physics, Tsukuba-shi, Ibaraki 305, Japan

Macro-elements of arbitrary smoothness are constructed on Clough-Tocher triangle splits. These elements can be used for solving boundary-value problems or for interpolation of Hermite data, and are shown to be optimal with respect to spline degree. We believe they are also optimal with respect to the number of degrees of freedom. The construction provides local bases for certain superspline spa...

The competing interests statement was incomplete and should have read: “Jean-Louis Vincent is the current chairman of the International Sepsis Forum, and a member of the steering committee of the Surviving Sepsis Campaign. His personal views do not necessarily refl ect those of the other members of these committees. The Surviving Sepsis Campaign has received funding from Eli Lilly, Baxter, and ...

The F-wave is a result of the backfire of α-motoneurons following an antidromic inva‐ sion of propagated impulses across the axon hillock (Kimura, 1974). Its occurrence reflects excitability changes in the spinal motor neurons, as reported in patients with spasticity (Odusote & Eisen, 1979) and in healthy subjects with isometric contraction (Suzuki, Fujiwara & Takeda, 1993). In our previous stu...

A new macro-element useful for finite element approximations to fourth order elliptic problems with curved boundaries is presented. An error analysis is given 2 which shows that these elements achieve 0(h ) accuracy in energy.

Macro-elements of smoothness C r on Clough-Tocher triangle splits are constructed for all r 0. These new elements are improvements on elements constructed in 11] in that (disproving a conjecture made there) certain unneeded degrees of freedom have been removed. Numerical experiments on Hermite interpolation with the new elements are included. A bivariate macro-element deened on a triangle T con...