نتایج جستجو برای: tap1
تعداد نتایج: 418 فیلتر نتایج به سال:
A series of chromophores y1–y3 based on the same bis(N,N-diethyl)aniline donor and the tricyanofuran acceptor (TCF) linked together via the modified thiophene π-conjugation with different isolated groups have been synthesized and systematically investigated in this paper. Density functional theory (DFT) was used to calculate the HOMO–LUMO energy gaps and first-order hyperpolarizability (β) of t...
This paper concerns the manner in which combinatorial mating proteins of the fungus, Schizophyllum commune, recognize one another to form complexes that regulate target gene expression. In Schizophyllum, tightly linked Y and Z mating-type genes do not promote development in the combinations present in haploid strains (i.e., self combinations). When the Y and Z genes from two different mating ty...
Introduction DNA methylation may provide critical insights into gene-environment interactions in inflammatory bowel disease (IBD). Methods Using the multi-centre IBD Character inception cohort (295 controls, 154 CD, 161 UC, 28 IBD-U), epigenome-wide was profiled using Illumina HumanMethylation450 platform. Differentially methylated position analysis performed age, sex and cell...
PURPOSE Defects in the antigen processing machinery (APM) may provide tumor cells with a mechanism to escape immune recognition. The purpose of this study is to determine the clinical significance of APM component down-regulation and tumor-infiltrating T cells in ovarian carcinoma. EXPERIMENTAL DESIGN After institutional review board approval, tumor samples from 150 patients with invasive epi...
IgA nephropathy (IgAN), major cause of kidney failure worldwide, is common in Asians, moderately prevalent in Europeans, and rare in Africans. It is not known if these differences represent variation in genes, environment, or ascertainment. In a recent GWAS, we localized five IgAN susceptibility loci on Chr.6p21 (HLA-DQB1/DRB1, PSMB9/TAP1, and DPA1/DPB2 loci), Chr.1q32 (CFHR3/R1 locus), and Chr...
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