نتایج جستجو برای: targeted peptide
تعداد نتایج: 304789 فیلتر نتایج به سال:
Potent sequence selective gene inhibition by siRNA 'targeted' therapeutics promises the ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, limited blood stability and non-specific immune stimulation. To address these problems, ligand-targeted, sterically stabilized nanoparticles have been adapted for siRNA. Self-assembling nanoparticles with siRNA we...
Abstract Background Targeted optical imaging offers a noninvasive and accurate method for the early detection of gastrointestinal tumors, especially flat appearances. In our previous study, sequence SNFYMPL (SNF) was identified as specific peptide to bind esophageal carcinoma using phage-display technology. This study aimed evaluate tumor-targeting efficacy Cy5.5-conjugated SNF probe in vitro v...
Mitochondrial β-barrel proteins are synthesized on cytosolic ribosomes and must be specifically targeted to the organelle before their integration into the mitochondrial outer membrane. The signal that assures such precise targeting and its recognition by the organelle remained obscure. In the present study we show that a specialized β-hairpin motif is this long searched for signal. We demonstr...
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