نتایج جستجو برای: taxane
تعداد نتایج: 2009 فیلتر نتایج به سال:
BACKGROUND It has been estimated that more than $8 billion is spent annually on the management of breast cancer in the United States. The taxane chemotherapeutic agents are cornerstones in the treatment of breast cancer, yet no study has assessed whether the choice of a taxane affects the economic outcomes of metastatic breast cancer treatment. OBJECTIVE To determine if differences exist in t...
سابقه و هدف: شیمی درمانی از اجزای درمان های تکمیلی پس از جراحی مبتلایان به سرطان پستان است. هدف این مطالعه، مقایسه کارایی رژیم های درمان تکمیلی taxane-based و anthracycline-based با cyclophosphamide, methotrexate و5-fluorouracil (cmf) بعد از جراحی ماستکتومی تعدیل شده(modified radical mastectomy ,mrm) از نظر مدت زمان فراغت از بیماری بود. مواد و روش ها: 62 بیمار مبتلا به سرطان پستان که تحت عمل جر...
Introduction. Biological markers as Her2/neu, p53, and hormonal receptors (HmRs) may be reliable parameters for prognostic assessment of patients of locally advanced breast cancer (LABC). This work aims at assessing the potential value of these biological markers for the prediction of disease outcome after neoadjuvant taxane-based chemotherapy and its implication on the surgical role. Patients ...
Microtubules (MTs) are components of the cytoskeleton made up of polymerized alpha and beta tubulin dimers. MT structure and function must be maintained throughout the cell cycle to ensure proper execution of mitosis and cellular homeostasis. The protein tyrosine phosphatase, PTPN13, localizes to distinct compartments during mitosis and cytokinesis. We have previously demonstrated that the HPV1...
Capecitabine in addition to anthracycline-taxane based regimens for patients with early breast cancer (EBC) has been reported in previous clinical trials, but the reported efficacy of this regimen remained inconsistent. In order to clarify the survival benefit of this regimen, a meta-analysis was performed. The systematic literature search was conducted in PubMed, the Cochrane library and Googl...
Prostate cancer progression requires active androgen receptor (AR) signaling which occurs following translocation of AR from the cytoplasm to the nucleus. Chemotherapy with taxanes improves survival in patients with castrate resistant prostate cancer (CRPC). Taxanes induce microtubule stabilization, mitotic arrest, and apoptotic cell death, but recent data suggest that taxanes can also affect A...
Despite widespread clinical use, delivery of taxane chemotherapeutics remains a challenge due to poor solubility and lack of selectively. Polymeric nanomicelle strategies have been pursued to overcome these issues; however current formulations are often limited by low drug loading and poor serum stability. To achieve a drug delivery system that addresses these issues, poly(D,L-lactide-co-2-meth...
INTRODUCTION The classical taxanes (paclitaxel, docetaxel), the newer taxane cabazitaxel and the nanoparticle-bound nab-paclitaxel are among the most widely used anticancer drugs. Despite years of research, the optimal dosing regimen (weekly vs 3-weekly) and optimal dose is still controversial, as is the value of pharmacological personalization of taxane dosing. AREAS COVERED This review prov...
Background: Primary treatment for gastric cancer with peritoneal dissemination is systemic chemotherapy because the effectiveness of cytoreductive surgery remains unclear. This study aimed to investigate the efficacy of cytoreductive surgery with systemic chemotherapy for advanced gastric cancer with peritoneal dissemination. Methods: From 2007 to 2014, 40 patients with peritoneal disseminated ...
INTRODUCTION We have recently described an increased lymphocytic infiltration rate in breast carcinoma tissue is a significant response predictor for anthracycline/taxane-based neoadjuvant chemotherapy (NACT). The aim of this study was to prospectively validate the tumor-associated lymphocyte infiltrate as predictive marker for response to anthracycline/taxane-based NACT. PATIENTS AND METHODS...
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