The goal of this teaching case study is to demonstrate the novel use of (99m)Tc-HMPAO-labeled white blood cells (WBCs) in diagnosing chronic recurrent multifocal osteomyelitis (CRMO). (99m)Tc-HMPAO-labeled white blood cells were utilized to diagnose CRMO. Classically, CRMO is evaluated scintigraphically using (99m)Tc-methylene diphosphonate/hydroxymethylene diphosphonate. (99m)Tc-HMPAO-labeled ...

Pulmonary involvement secondary to Waldenstrom's macroglobulinemia (WMG) is described in a 40-year-old male by incidental findings on a bone scan. He was examined for right leg pain, and bone scan revealed unexpected pulmonary uptake of Tc-99m MDP. CT scan of the thorax revealed pleural effusion and slightly disseminated micronoduler density increase in the right lung and parenchymal infiltrati...

Clinical Classification of Pulmonary Calcification and Ossification Proposed Mechanisms of Ectopic Lung Calcification and Ossification Role of Relative and Absolute Calcium Excess Role of an Alkaline Environment Role of Lung Injury or Fibrosis Role of Angiogenesis Imaging Chest Roentgenogram Computed Tomography 99m Tc-MDP Bone Scintigraphy Specific Disorders Pulmonary Metastatic Calcification P...

A 57-year-old woman with a newly diagnosed lung cancer was referred for a bone survey as a part of cancer workup. An interesting finding on Tc-99m MDP bone scan was accumulation of radioactivity in the bowel, on account of self urine drinking before the imaging. Many people believe that drinking their own urine has a myriad of health benefits, nevertheless, none of which have been scientificall...

We report a 41 years old man with rapidly growing and tender lump on the anteromedial surface of tibia. The patient had the history of gastrectomy and gastrojejunostomy due to gastric carcinoma. On admission, the Simple X-ray of lower extremity disclosed a slight thinning of the anterior cortex of tibia without cortical destruction. The whole-body bone scan with (99m)TC MDP revealed activity of...

Multiple benign osteolytic lesions are very hard to differentiate from disseminated bone metastasis. Whole-body bone scintigraphy (WBBS) with technetium-99m methylene diphosphonate (Tc-99m MDP) demonstrates multiple lesions with increased uptake in any bone involved. Even combined with medical history and multiple imaging results, such as MRI and CT, the clinical diagnosis of metastasis lesion ...

Exosomes known as nano-sized extracellular vesicles attracted recent interests due to their potential usefulness in drug delivery. Amid remarkable advances in biomedical applications of exosomes, it is crucial to understand in vivo distribution and behavior of exosomes. Here, we developed a simple method for radiolabeling of macrophage-derived exosome-mimetic nanovesicles (ENVs) with (99m)Tc-HM...

A number of people suffered rhabdomyolysis caused by eating crayfish in China and the final diagnosis was a rare disease called Haff disease. In this study, we present a 26 years old man with a history of severe muscular soreness for whole body after eating crayfish and this status lasted for about 3 months. Blood analysis showed significant increase in serum creatine kinase and lactate dehydro...

UNLABELLED Technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) as a static renal agent is currently the most frequently used agent in the detection of renal scarring, and allows accurate calculation of differential renal function (DRF). But this agent has some disadvantages such as relatively higher radiation dose and time consumption. METHODS The purpose of this study was to evaluate the po...

Focal tracer uptake in the jaw during conventional bone scintigraphy is a quite frequent finding usually due to dental disease and seldom to other diseases including malignant disease. Methylene diphosphonate-technetium-99m ((99m)Tc-MDP) 3-phase bone scan is considered the most sensitive imaging method for the detection of jaw osteonecrosis at an early stage. This finding can also but seldom be...