Hedgehog proteins are secreted morphogens that play critical roles in development and disease. During maturation of the proteins through the secretory pathway they are modified by the addition of N-terminal palmitic acid and C-terminal cholesterol moieties, both of which are critical for their correct function and localisation. Hedgehog acyltransferase (HHAT) is the enzyme in the endoplasmatic ...

1 Positive strand RNA viruses generally replicate in large membrane associated complexes. For 2 poliovirus, these replication complexes are anchored to the membrane via the viral 2B, 2C, and 3 3A proteins. 2C is an AAA+ family ATPase that plays a key role in host cell membrane 4 rearrangement, is a putative helicase, and is implicated in virion assembly and packaging. 5 However, the membrane bi...