DNA nanostructures prepared by self-assembly possess good stability, high biocompatibility, and low immunogenicity as drug delivery vehicles. In this work, DNA tetrahedron (TD) was constructed and modified with SL2B aptamer (S) and folic acid (F). TD possessed a small diameter (~6 nm) and entered into the nucleus quickly. SL2B aptamer can inhibit cancer cell growth by disturbing vascular endoth...

BACKGROUND/AIMS One of psychology's challenges is to develop and evaluate sensitive tests in the area of social cognition. Yet, there are few available scales that can measure mild deficits in social understanding, especially for typically developing (TD) populations. The Reading the Mind in the Eyes Test (children's version) was translated and adapted for use in the Greek language [RMET-G (chi...

TD(λ) is a core algorithm of modern reinforcement learning. Its appeal comes from its equivalence to a clear and conceptually simple forward view, and the fact that it can be implemented online in an inexpensive manner. However, the equivalence between TD(λ) and the forward view is exact only for the off-line version of the algorithm (in which updates are made only at the end of each episode). ...

Thanatophoric dysplasia (TD) is caused by mutation of the gene that encodes fibroblast growth factor 3 (FGFR3). Owing to the poor prognosis for TD, prenatal diagnosis is critical to optimal perinatal management. We report here a case of TD in twin pregnancy, which was prenatally diagnosed by DNA analysis following amniocentesis at 15 weeks, and was managed by selective fetal termination. Prenat...

An approach is developed to describe the evolution of threading dislocation ~TD! densities in lattice-mismatched epitaxial films. TD ensembles are treated in close correspondence to chemical species in chemical reaction kinetics. ‘‘Reaction rate’’ equations are derived for changing TD density with increasing film thickness for firstand second-order reactions. Selective area growth is an example...

Multidrug-resistant Salmonella enterica serovar Typhimurium ST313 has emerged in sub-Saharan Africa causing severe infections in humans. Therefore, it has been speculated that this specific sequence type, ST313, carries factors associated with increased pathogenicity. We assessed the role in virulence of a gene with a yet unknown function, st313-td, detected in ST313 through comparative genomic...

Objective: The aim of the study was to survey the frequency of tardive dyskinesia (TD) in patients with schizophrenia and its demographic and clinical correlates in selected Asian countries. Method: A total of 6,761 hospitalized schizophrenia patients in nine Asian countries and territories were examined from 2001 to 2009. TD was evaluated as “present” or “absent” according to the clinical judg...

Some patients with nonsmall-cell lung cancer (NSCLC) without epidermal growth factor receptor (EGFR) mutations still respond to gefitinib and erlotinib, suggesting that there may be a mechanism(s) other than the EGFR pathway that mediates the tumoricidal effects. In the current study, we tested the efficacy of TD-19, a novel compound chemically modified from erlotinib, which has more potent apo...

BACKGROUND Echocardiographic measurements of left ventricular (LV) myocardial displacement may produce different results depending on the choice of employed modality and subjective adjustments during data acquisition and analysis. METHODS In this study, left ventricular longitudinal systolic displacement was quantified in 57 patients (31 women and 26 men, 50 +/- 16 years) using colour (colour...

Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7-17years. Dysregulation was defined by the sum of T-scores of Attention, Aggressi...