objective(s) the role of therapeutic drug monitoring (tdm) in patient care has grown rapidly since its introduction three decades ago. the aim of present study was to evaluate the possible relationship between serum levels and the clinical response of valproic acid (vpa). materials and methods in the present study we evaluated a homogeneous group of adult patients receiving vpa monotherapy. a t...

Iron is essential for living organisms and the disturbance of iron homeostasis is associated with altered immune function. Additionally, bacterial infections can cause major complications in instances of chronic iron overload, such as patients with transfusion-dependent thalassemia. Monocytes and macrophages play important roles in maintaining systemic iron homoeostasis and in defense against i...

Technical debt (TD) is a metaphor for taking shortcuts or workarounds in technical decisions to gain short-term benefit in time-to-market and earlier software release. In this study, one large software development organization is investigated to gather empirical evidence related to the concept of technical debt management (TDM). We used the exploratory case study method to collect and analyze e...

Efficacy of therapeutic drug monitoring (TDM) of vancomycin (VCM) was retrospectively investigated in 184 patients with methicillin-resistant Staphylococcus aureus (MRSA) infection. The incidence of nephrotoxicity was compared between the patients who received TDM practice (TDM group, n=73) and did not (non-TDM group, n=111). Creatinine clearance (CLcr) values decreased significantly after the ...

Recent outbreaks of bacterial infection leading to human fatalities have been a motivational force for us to develop antibacterial agents with high potency and long-term stability. A novel cobalt (Co) based metal-organic framework (MOF) was tested and shown to be highly effective at inactivating model microorganisms. Gram-negative bacteria, Escherichia coli (strains DH5alpha and XL1-Blue) were ...

In the current technology dominated world, interoperability of systems managed by different organisations is an essential property enabling the provision of services at a global scale. In the Text and Data Mining field (TDM), interoperability of systems offering access to text corpora offers the opportunity of increasing the uptake and impact of TDM applications. The global corpus of all resear...

A monoclonal antibody (TDM-2) specific to a UV-induced cyclobutane pyrimidine dimer (T[cis-syn]T) has previously been established; however,the immunization had used UV-irradiated calf-thymus DNA containing a heterogeneous mixture of photoproduct sites. We investigated here the structural requirements of antigen recognition by the antibody using chemically synthesized antigen analogs. TDM-2 boun...

Therapeutic Drug Monitoring (TDM) is a routinely practised clinical laboratory technique which aids the clinicians with a clear clinical judgement of the drug therapy and optimize the doses if necessary. Rifampicin is the most important and potent component of first line therapy of tuberculosis (TB). Several factors like age, weight, gender, doses and formulations, gastro-intestinal disorders, ...

The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly altered due to the dynamic, unpredictable pathophysiological changes that occur in critical illness. For many drugs, significant increases in the volume of distribution and/or variability in drug clearance are common. When "standard" beta-lactam doses are used, such pharmacokinetic changes can result in...