Melanoma is a recalcitrant disease in need of transformative therapuetics. The present study used a patient-derived orthotopic xenograft (PDOX) nude-mouse model of melanoma with a BRAF-V600E mutation to determine the efficacy of temozolomide (TEM) combined with tumor-targeting Salmonella typhimurium A1-R. A melanoma obtained from the right chest wall of a patient was grown orthotopically in the...

The anti-glioma effect of temozolomide (Tem) is sometimes undermined by the emerging resistance. Recently, resveratrol (Res), herbal medicine extracted from grape seeds, has been demonstrated for its potential use in chemosensitization. In the current study, both these drugs were loaded simultaneously into nanoparticles with methoxy poly(ethylene glycol)-poly epsilon caprolactone (mPEG-PCL) as ...

Leukocyte transendothelial migration (TEM) is regulated by several signaling pathways including Src family kinases (SFK) and the small RhoGTPases. Previous studies have shown that vascular endothelial-cadherin (VE-cad) forms a complex with β-,γ-, and p120-catenins and this complex disassociates to form a transient gap during leukocyte TEM. Additionally, p120-catenin (p120-1A) overexpression in ...

In this invited talk, I will suggest where we are in our use of TEM for imaging extended defects and guess where we are going. Since the topic of this Symposium concerns advances in imaging and quantification of strain, local atomic structure, and the chemistry of extended defects, the present talk will emphasize the history and development of diffraction contrast methods for the analysis of ex...

Since the first communication describing an organism that produces an enzyme capable of hydrolyzing extended-spectrum cephalosporins (5, 6), several outbreaks of Enterobacte-riaceae resistant to oxyimino-␤-lactams have been reported. In these cases, the adopted survival strategy of bacteria challenged by the introduction of aztreonam, cefotaxime, ceftazi-dime, and other oxyimino-␤-lactams was t...