Inhibin, which is important for normal gonadal function, acts on the pituitary gonadotropins to suppress folliclestimulating hormone (FSH) secretion. The level and cellular localization of the inhibin isotypes, alpha, betaA and betaB, in the testis of mice were examined during postnatal development in order to determine if inhibin expression is related to testicular maturation. Mouse testes wer...

As one of the non-classical major histocompatibility complex(MHC)-1 antigens, Human Leukocyte Antigen G (HLA-G), has been suggested as a prognostic marker to identify the embryo developmental potential. In the present study, we investigated the potential roles of HLA-G in human spermatogenesis and early embryonic development. Quantitative real-time PCR analysis revealed that HLA-G's expression ...

The epithelial lining of the epididymal duct expresses the androgen receptor (Ar) along its entire length and undergoes rapid and profound degeneration when androgenic support is withdrawn. However, experiments involving orchidectomy with systemic testosterone replacement, and testicular efferent duct ligation, have indicated that structural and functional integrity of the initial segment canno...

BACKGROUND During the past decade, studies of human cancer have begun to yield molecular information on the identify of the multiple genetic changes in the development and progression of tumorigenesis. We investigated alterations of p53 and genomic instability in testicular tumors. MATERIALS AND METHODS Polymerase chain reaction (PCR) single-strand conformation polymorphism was performed for ...

Enkephalins play a major role in reproductive physiology in crustaceans; however their role in reproductive development in insects is largely unknown. We investigated the effect of exposure to exogenous leucine-enkephalin (Leu-Enk), methionine-enkephalin (Met-Enk), and the opioid antagonist naloxone on gonad development in the Eastern lubber grasshopper, Romalea microptera. Injection of either ...

To identify Kraft liquor effects on spermatogenesis and sperm motility of Caspian kutums by using in vitro culture, the fish testis was incubated with 5, 10 and 15 % (V/V) of liquor for 3 and 6 days. The percentage of motile spermatozoa and its total duration were also measured. Adverse effects on testicular cells were more apparent with the increase of liquor concentrations. The mean size of s...

The commonest reproductive disorders in human males at birth (cryptorchidism, hypospadias) or young adulthood (low sperm counts, testis germ cell cancer) may comprise a ‘testicular dysgenesis syndrome’ (TDS) resulting from fetal testis dysfunction. We and others have developed an animal model for TDS, involving in utero exposure of pregnant rats to di-n-butyl phthalate (DBP), which is a common ...

The commonest reproductive disorders in human males at birth (cryptorchidism, hypospadias) or young adulthood (low sperm counts, testis germ cell cancer) may comprise a ‘testicular dysgenesis syndrome’ (TDS) resulting from fetal testis dysfunction. We and others have developed an animal model for TDS, involving in utero exposure of pregnant rats to di-n-butyl phthalate (DBP), which is a common ...

OBJECTIVE To present clinical, chromosomal and hormonal features of ten cases with SRY-positive 46,XX testicular disorder of sex development who were admitted to our infertility clinic. CASES AND METHODS Records of the cases who were admitted to our infertility clinic between 2004 and 2015 were investigated. Ten 46,XX testicular disorder of sex development cases were detected. Clinical, hormo...