Cadmium (Cd) is one of the most toxic environmental heavy metals to organisms. The prominent toxic effects of Cd on reproductive organs are very well known. Gonad histopathology is a valuable tool for the assessment of endocrine disruption compounds EDCs effects on fish. The aim of this study was to evaluate the reproductive toxicity of cadmium chloride (CdCl2) on histopathology of Zebrafish (D...

1 (Oral/Poster) MULTICELLULAR HUMAN TESTICULAR ORGANOID: A NOVEL IN VITRO GERM CELL AND TESTICULAR TOXICITY MODEL Samuel Pendergraft, MS1, Hooman Sadri-Ardekani, MD, PhD2, Tanya Reid, BS3, Anthony Atala, MD2 and Colin Bishop, PhD1 1(1) Molecular Medicine and Translational Science Graduate Program, Wake Forest University Health Sciences, Winston-Salem, NC (2) Wake Forest Institute for Regenerati...

Previous work has shown that gap junction intercellular communication (GJIC) enhances cisplatin (Pt) toxicity in testicular tumor cells but decreases it in non-tumor testicular cells. In this study, these different GJIC-propagated effects were demonstrated in tumor versus non-tumor cells from other organ tissues (liver and lung). The downregulation of GJIC by several different manipulations (no...

Background Background: Mammalian spermatogenesis is regulated through paracrine and endocrine activity, specific cell signaling, and local control mechanisms. These highly specific signaling interactions are effectively absent upon placing testicular cells into two-dimensional primary culture. The specific changes that occur between key cell types and involved spermatogenesis signaling pathways...

The objective of this study was to evaluate inducible nitric oxide synthase (iNOS) and nuclear factor-kappaB inhibitor (NF-kappaB) expression and the potential chemoprotective effects of an NF-kappaB inhibitor, pyrrolidine dithiocarbamate (PDTC), against cisplatin-induced testicular damage in rats. Rats were divided into 4 equal groups: group 1, control; group 2, injected with cisplatin (CIS) f...

Background and objectives: Diazinon (O,O-diethyl O-2-isopropyl-6- methyl pyrimidinyl-4-g-1- phosphorothioate) is one of  the organophosphate insecticides for different agricultural and gardening uses, which can be highly toxic. Zingiber officinale(ginger), a spice and herbal medicine, has antioxidant and anti-inflammatory properties. This study has investigated the eff...

Busulfan is known to cause several adverse effects including reproductive toxicity in humans. Garlic (Allium sativum), a widely distributed medicinal plant, is highly regarded for its medicinal activities including antioxidant property.This study was conducted to assess whether garlic extract could serve as protective agents against testicular toxicity during busulfan treatment in a mi...

Abstract Background Tramadol provokes oxidative stress that gives rise to apoptosis with alterations in the cellular structure and adversely influences male fertility. A specific inhibitor of nuclear factor kappa B (NF-κB), pyrrolidine dithiocarbamate (PDTC), has observable antioxidant anti-inflammatory characteristics enhances improvement organs damage caused by various agents. The impact PDTC...