The early cytokines production in response to live logarithmic and stationary phase promastigotes of Leishmania major was examined on the peripheral blood cells of the healthy individuals. Whole blood cultures were stimulated by either logarithmic or stationary phase promastigotes. IFN- and IL-10 productions were assessed by specific sandwich ELISA. The results showed that the logarithmic prom...

Objective(s):MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the different stages of tumor development and metastasis. To study the effect of silibinin on miRNAs expression, we evaluated quantitative expression of miR-21 and miR-155 as two oncomiRs and seve...

background : mdm2, e-cadherin, survivin and her2 genes are involved in the regulation of normal cell growth. however, any crucial change in their expression levels can convert a normal cell into a cancer cell. numerous studies have identified alterations of these gene expression levels in various cancers, particularly in breast cancer. thus, they may be used as diagnostic biomarkers. in this ex...

background: modulation of the immune response is an important strategy by which establish­ment and growth of hydatid cyst in the internal organs of human is warranted. induction of apop­tosis in the lymphocytes might be a considerable component. this study was designed to evaluate apoptotic impact of hydatid fluid (hf) on human lymphocytes. methods: human lymphocytes were treated with hydatid f...

T o prevent chromosome segregation errors, cytokinesis in Saccharomyces cerevisiae awaits the arrival of a spindle pole body (SPB) in the bud. On page 335 , Fraschini et al. show that this arrival is announced by the mother-bound SPB, which heralds the onset of cytokinesis and mitotic exit. Mitotic exit relies on a G-protein called Tem1, which activates the destruction of mitotic cyclins. As Te...

Background: The unique expression of fibromodulin (FMOD) in patients with chronic lymphocytic leukemia (CLL) has been previously reported. Detecting FMOD in CLL patients using specific anti-FMOD mAbs might provide a promising method in detection, monitoring, and prognosis of CLL. Objectives: In this study, we aimed for producing specific antibodies agains...

We present a brief review of recent advances in string cosmology. Starting with the Dilaton-Moduli Cosmology (known also as the Pre Big Bang), we go on to include the effects of axion fields and address the thorny issue of the Graceful Exit in String Cosmology. This is followed by a review of density perturbations arising in string cosmology and we finish with a brief introduction to the impact...