Alternative pre-mRNA splicing is an important element in eukaryotic gene expression, as most of the protein-coding genes use this process to generate multiple protein isoforms from a single gene. An increasing number of human diseases are now recognized to be caused by the selection of 'wrong' alternative exons. Research during the last few years identified a number of low-molecular-mass chemic...

Facility design does not stop when the fixed architectural and acoustical components are in place. Spaces live and breathe with the people who reside in them. Research and examples show that noise — auditory clutter — thrives on itself in hospitals. Whether the result of the wrong conversation in the wrong place or the right conversation in an unfortunate place, talk mixed with sounds of techno...

Recently philosophers have proposed a wide variety of interventions referred to as 'moral enhancements'. Some of these interventions are concerned with helping individuals make more informed decisions; others, however, are designed to compel people to act as the intervener sees fit. Somewhere between these two extremes lie interventions designed to direct an agent's attention either towards mor...

Objective To correct patient identification for surgery nd reduce risk of wrong site surgery. Surgical care is high risk and complex and errors are associated with huge negative implications. The need to identify patients correctly before surgeries is important to reduce risk of wrong-site surgeries. Operating theatres (OT) are a highly stressful work environment where time and resources are pr...