Biological agents targeting inflammatory skin diseases have dramatically overcome many of the limitations older oral therapeutic options. Among various biological agents, ixekizumab is a humanised monoclonal antibody that blocks activity IL-17A, which exhibited high efficacy against psoriasis. Although there are limited number cutaneous adverse reactions, biologic-induced type I allergic reacti...

Breast Cancer Treatment In article number 2107550, Wassana Yantasee and co-workers develop polymer-decorated mesoporous silica nanoparticles for HER2-positive breast cancer treatment. This patented versatile platform can co-deliver multiple therapeutic classes to ensure that they reach the target cells at same time fully realize their synergy. Illustrated herein are with three drug cargos: HER2...

Enhancing myelin repair remains an important therapeutic goal in primary demyelinating diseases of the central nervous system (CNS) such as multiple sclerosis (MS). The emerging heterogeneity of pathology within MS lesions, and differential oligodendrocyte survival in particular, suggests that therapeutic strategies may need to be tailored to an individual patient's requirements. A number of th...

Cancer is still a major factor threatening human life around the world, and anticancer drugs remain huge unmet clinical need. Here, we reviewed novel including new molecular entities therapeutic biologics approved in US, EU, Japan, China that represent main advances drug research development 2020. Small molecule inhibitors targeting oncogenes, antibodies, antibody conjugates (ADCs) are were Mor...

More than 20 monoclonal antibodies have been approved as therapeutic drugs by the US Food and Drug Administration, and it is quite likely that the number of approved antibodies will double in the next 7-10 years. Antibody drugs show several desirable characteristics, including good solubility and stability, long persistence in the body, high selectivity and specificity, and low risk for bioconv...

Tn[GalNAc(α1-3)-Ser/Thr] antigen, a tumor-associated carbohydrate antigen, is highly expressed in various tumors and an attractive candidate for cancer immunotherapy. The generation of an anti-Tn antibody is a first step toward the construction of new anticancer molecules. However, because of the simple and small conformation of the Tn molecule, it is difficult to generate an anti-Tn antibody f...

The 23rd Annual Antibody Engineering, 10th Annual Antibody Therapeutics international conferences, and the 2012 Annual Meeting of The Antibody Society, organized by IBC Life Sciences with contributions from The Antibody Society and two Scientific Advisory Boards, were held December 3-6, 2012 in San Diego, CA. The meeting drew over 800 participants who attended sessions on a wide variety of topi...

Acetaminophen (APAP) overdoses are of major clinical concern. Growing evidence underlines a pathogenic contribution of sterile postinjury inflammation in APAP-induced acute liver injury (APAP-ALI) and justifies development of anti-inflammatory therapies with therapeutic efficacy beyond the therapeutic window of the only current treatment option, N-acetylcysteine (NAC). The inflammatory mediator...

background: lung carcinoma is a multiple type cancer comprising of small cell and non-small cell carcinomas (nsclc). for therapeutic and diagnostic purposes, serum monoclonal antibodies have been produced against lung cancer. objective: to charac-terize a murine monoclonal antibody (me3d11) reactive with human nsclc. methods: a murine monoclonal antibody (me3d11) reactive with human nsclc was s...

conclusions it was concluded that the efficacy of tramadol and fluoxetine in males with premature ejaculation are the same and both are effective. both of these drugs are safe to treat premature ejaculation. results thirty-six subjects with the mean age of 44 ± 19.3 years underwent analysis. eighteen subjects were treated by fluoxetine and 18 by tramadol. the efficacy of treatment in the two gr...