The aim of this study was to analyze the location, the cause and treatment of iatrogenic gastrointestinal perforations following therapeutic endoscopic procedures. Perforation occurred in 12 patients out of 3,389, giving cases occurred intraoperatively or postoperatively. Among them, 6 cases were closed by titanium clipping and 1 case by purse string suture. In another case after cap-assisted e...

OBJECTIVE The concept of disease activity in Graves' ophthalmopathy (GO) might explain why as many as one-third of patients do not respond to immunosuppressive treatment, because only patients in the active stage of disease are expected to respond. The hypothesis was adopted that a parameter used to measure disease activity should be able to predict a response to immunosuppressive treatment. Th...

The bone surrounding a prosthetic implant normally experiences a progressive quantitative reduction as a result of stress shielding and wear debris production, that can lead to the aseptic loosening of the implant. Dual-energy X-ray absorptiometry (DXA), using software algorithms, can ensure a surrogate measure of load redistribution after the implant of the prosthetic components and can be a v...

BACKGROUND Evaluation of treatment programs in addiction field is a prerequisite to improve the quality of care. This study aimed to investigate the effectiveness of Therapeutic Community (TC) program in Iran. METHODS Individuals who had voluntarily enrolled in the TC center within a period of seven years, from early 2005 to late 2011, entered the study. Those who successfully completed the 1...

Infection associated hemophagocytic syndrome is increasingly recognized as a potentially fatal complication of dengue fever. It should be suspected with prolonged fever beyond seven days associated with hepatosplenomegaly, hyperferritinemia, worsening cytopenias and development of multiorgan dysfunction. Surge of similar pro-inflammatory cytokines observed in dengue associated hemophagocytic sy...

Multimodal therapy of glioblastoma (GBM) reveals inter-individual variability in terms of treatment outcome. Here, we examined whether a miRNA signature can be defined for the a priori identification of patients with particularly poor prognosis.FFPE sections from 36 GBM patients along with overall survival follow-up were collected retrospectively and subjected to miRNA signature identification ...

In permanent temporomandibular disc displacement (TMJ-DD) outcome studies many authors claim positive effects of arthroscopic surgery, arthrocentesis and physical therapy. This literature review was undertaken to analyse whether the claimed effects are based on acceptable methodology. The recorded papers were analysed by two independent observers according to (1) method of investigation, (2) th...

Background: :This study was conducted to analyze the clinical features and therapeutic outcome for brain abscesses caused by gram negative bacilli. Methods: 41 patients with gram negative bacillary brain abscess, out of a total of 278 cases, 25 males and 16 female aged 2-72 years were reviewed at IMS, BHU and JN Medical College Hospital AMU, over a 17 year period for Predisposing factors, clini...

We would like to thank the interest paid to our study and the valuable comments regarding it.(1) Herein, we clarify the comments and questions raised. Despite advances in cardiopulmonary resuscitation, cardiac arrest is still associated with high morbidity and mortality.(2) Survival of these patients depends on the quality of care, and despite the fact that basic and advanced life support have ...

A broader understanding of factors underlying interindividual variation in pharmacotherapy is important for our pursuit of "personalized medicine." Based on knowledge gleaned from the investigation of human genetics, drug-metabolizing enzymes, and transporters, clinicians and pharmacists are able to tailor pharmacotherapies according to the genotype of patients. However, human host factors only...