obesity with an increasing prevalence rate worldwide is correlated with multiple comorbidities. unfortunately, the currently available therapies such as the pharmacotherapy, bariatric surgery or gene-transfer technology are associated with a number of disadvantages including undesirable side effects, poor compliance or transient effectiveness. therefore, modifications of the lifestyle factors m...

sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. sirolimus must be used within a narrow therapeutic window. due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. t...