As a kind of promising drug carriers, smart polymers have attracted much attention due to the effective and controlled release in target cells. Herein, reactive oxygen species (ROS)-responsive thioether-containing amphiphilic hyperbranched polymer prepared from MTPA TMPTGE (HBPMT) is synthesized 3-(methylthio)propylamine (MTPA) trimethylolpropane triglycidyl ether (TMPTGE) by amine-epoxy click ...

The thioether-functionalized aminosilanes Me2Si(NH-C6H4-2-SR)2 (R=Ph, Me) were lithiated with n-BuLi and subsequently allowed to react CuCl in the presence of PMe3. In case Me2Si(NH-C6H4-2-SPh)2, dinuclear complex [Cu2{Me2Si(NC6H4-2-SPh)2}(PMe3)2] was isolated. copper atoms adopt a distorted trigonal-planar coordination (Cu−N: 191.2(2) pm, Cu−P: 216.3(1) Cu−S: 244.4(1) pm). reaction Li2Me2Si(N-...

Many biologically active peptides found in nature exhibit a bicyclic structure wherein a head-to-tail cyclic backbone is further constrained by an intramolecular linkage connecting two side chains of the peptide. Accordingly, methods to access macrocyclic peptides sharing this overall topology could be of significant value toward the discovery of new functional entities and bioactive compounds....

New group 11 metal complexes have been prepared using the previously described tripodal bis(imidazole) thioether ligand (N-methyl-4,5-diphenyl-2-imidazolyl)2C(OMe)C(CH3)2S(tert-Bu) ({BITOMe,StBu}, 2). The pincer ligand offers a N2S donor atom set that can be used to coordinate the group 11 metals in different oxidation states [AuI, AuIII, AgI, CuI and CuII]. Thus the new compounds [Au{BITOMe,St...

Deprotection of an N(α)-Fmoc-protected glycocysteine derivative 7 with an excess of morpholine unexpectedly led to the fluorenylmethyl-protected thioether 8 in high yield. The suggested mechanism for this reaction comprises the addition of the cysteine thiolate on the exocyclic double bond of dibenzofulvene, which is formed during Fmoc deprotection. The influence of base concentration on this t...

c-Type cytochromes contain haem covalently attached to protein by thioether bonds formed post-translationally and requiring a dedicated biogenesis apparatus. Three biogenesis systems, found in different cell types, are well known. Here we discuss emerging evidence for at least one additional system, for unanticipated diversity in the location of the systems and for the co-existence of multiple ...