Click chemistry is a powerful technology for the functionalization of therapeutic proteins with effector moieties, because of its potential for bio-orthogonal, regio-selective, and high-yielding conjugation under mild conditions. Designed Ankyrin Repeat Proteins (DARPins), a novel class of highly stable binding proteins, are particularly well suited for the introduction of clickable methionine ...

Selective nucleophilic substitution on a perfluorophenyl unit comprising a BODIPY fluorophore using an alkanethiol or a primary amine offers a quantitative fluorophore labelling strategy, while retaining high photostability and emission quantum yields approaching unity.

despite development of new approaches for the treatment of cancer disease, it is the second cause of mortality in world. annually, 30000 persons die in iran due to cancer diseases. eighty percent of cancer patients are children which about 50% children lead to death. given the high rate of cancer-related death, the new approaches for prevention, control, early diagnosis, and treatment of this d...

The increasing accumulation of toxic heavy metals in the environment has generated need efficient removal systems, being adsorption method most popular one applied aqueous solutions. Of particular concern is case Pb 2+ , Cd and Hg due to their high potential hazard. In this paper, we describe feasibility a new family nanomaterials, swelling charge micas, these cations from Batch experiments wer...

A solution method for preparing surface functionalized colloidal silicon quantum dots (SiQDs) is presented. SiQDs prepared by this method are reasonably monodispersed and can be further functionalized via thiol-ene click reactions to introduce specific functionalities (i.e. -NH(2), -COOH, -SO(3)(-), alkane, alkene).

A simple and modular synthetic approach, based on miniemulsion polymerization, has been developed for the fabrication of composite polymer-metal nanoparticle materials. The procedure produces well-defined composite structures consisting of gold, silver or MnFe(2)O(4) nanoparticles (∼10 nm in diameter) encapsulated within larger spherical nanoparticles of poly(divinylbenzene) (∼100 nm in diamete...

Biosensors based on Electrochemical Impedance Spectroscopy (EIS) detect the binding of an analyte to a receptor functionalized electrode by measuring subsequent change in extracted charge-transfer resistance (R CT ). In this work, stability long chain alkanethiol, 16-mercaptohexadecanoic acid was compared that polymer-based surface linker, ortho-aminobenzoic (o-ABA). These two classes linkers w...

in this study, kinetics and mechanism of the sulfur dioxide adsorption on the single-walled carbon nanotubes (cnt) are investigated. three single-walled carbon nanotubes, including the armchair (6,6), chiral (6,5) and zigzag (6,0) cnts were chosen as the models and the different orientations of so2 molecule relative to the cnt axis were considered. the b3lyp functional within the 6-31g(d) basis...

The structure and morphology of nonmaterial formed by colloidal synthesis represent a subject of interest as it is a factor deciding the physicochemical properties and biological applications of nanostructures. Among various nanoparticles, gold can develop fractal assembled patterns. Herein, we report a nano-aggregate of a thiol-on-gold self-assembled structure and the influence of β-cyclodextr...