5 -Hydroxy-2-formylpyridine thiosemicarbazone (5-HP) is highly active intraperitoneally against leukemia L-1210, Ehrlich ascites carcinoma, and lymphoma L-5 178Y over a broad dose range. 5-HP is also active on leukemia L-l210 and the Ehrlich ascites carcinoma by delayed treatment. Activity by oral routes or subcutaneously is poor. Moderate activity is displayed against the Lewis lung carcinoma ...

carcinosarcoma 256 (7, 10) was markedly inhibited by kethoxal bis(thiosemicarbazone). After discontinuation of treatment the inhibition was persistent and was followed by complete tumor regression in a substantial percentage of cases (7). Moreover, KTS2 inhibited the growth of 5 other transplantable rodent tumors (7, 10). Impairment of spontaneous mammary tumors was caused by KTS in DBA/2 (7), ...

A new dissymmetric bis(thiosemicarbazone) ligand, H2L2, containing a 4-(1-naphthyl)-3-thiosemicarbazone branch has been easily prepared and characterized. The reactivity of this ligand the hybrid isopropylthiosemicarbazone/naphtoylhydrazone, H2L1, with zinc(II), copper(II) nickel(II) nitrates in presence different amounts lithium hydroxide explored. results show that although both ligands prese...

A series of metal complexes of Zn(II) and Hg(II) having the general composition [M(L)(2)]X(2) [where L = 2-formylpyridine thiosemicarbazone; M = Zn(II) and Hg(II); X = Cl(-), NO(3) (-) and 1/2SO(4) (2-)] have been prepared and characterized by elemental chemical analysis, molar conductance, and spectral (IR and mass) studies. The IR spectral data suggests the involvement of sulphur and azometha...

Preparation of bisbenzofuran-2-yl-methanone (1), the corresponding ketoxime 4, semicarbazone and thiosemicarbazone 3a and 3b, ether derivatives of the ketoximes 5a-j and the alcohol 2 are described. These substances have been prepared in excellent yields. All the synthesized compounds except 5i have been tested against five different microorganisms and some of them were found to be active again...

5 -Hydroxy-2-formylpyridine thiosemicarbazone (5-HP) is highly active intraperitoneally against leukemia L-1210, Ehrlich ascites carcinoma, and lymphoma L-5 178Y over a broad dose range. 5-HP is also active on leukemia L-l210 and the Ehrlich ascites carcinoma by delayed treatment. Activity by oral routes or subcutaneously is poor. Moderate activity is displayed against the Lewis lung carcinoma ...

A new thiosemicarbzone compound was prepared by the reaction of acenaphthenequinone and thiosemicarbazide (1:1 molar ratio) in absolute methanol at 70°C. The crystal structure of this compound, acenaphthenequinone thiosemicarbazone mono methanol, was determined by X-ray crystallography. The unit cell parameters are as follows: a = 7.0384(14) Ǻ, b = 14.202(3) Ǻ, c = 14.270(3) Ǻ, β = 104.26(3)°. ...

The synthesis of a new tridentate Schiff-base thiosemicarbazone ligand (HL) that derived from the reaction ((R)-2-((4-(dimethylamino)phenyl)((2-nitrophenyl)amino)methyl)-5,5-di methyl- cyclohexane-1,3-dione with thiosemicarbazide is reported. title ligand(E)-2-((R)-2-((R)-(4-(dimethylamino)phenyl)((2-nitrophenyl)amino)methyl)-5,5-dimethyl-3-oxocyclohexylidene)hydrazine-1-carbothioamide selected...

BACKGROUND The thiosemicarbazone CD 02750 (VLX50) was recently reported as a hit compound in a phenotype-based drug screen in primary cultures of patient tumor cells. We synthesized a copper complex of VLX50, denoted VLX60, and characterized its antitumor and mechanistic properties. MATERIALS AND METHODS The cytotoxic effects and mechanistic properties of VLX60 were investigated in monolayer ...