investigate its toxicity to the rat. They noted that animals dying after sulphaguanidine showed goitres which on microscopical section were found to be due to hyperplasia and were practically free from colloid. The same effect was produced more or less by other sulpha drugs such as sulphadiazine and sulphapyridine, and Richter and Clisby (1942) showed that other sulphur compounds, notably thiou...

The recent discovery of the rodenticidal properties of a-naphthylthiourea (ANTU) by Richter (1) has aroused interest in the mechanism by which this compound produces its acute toxic effects in animals. Factors associated with the toxicity of ANTU such as (a) the high toxicity to Norway rats, (b) the lower toxicity to most other species, (c) the development of tolerance after administration of s...

The first studies on thiourea in this department were undertaken for reasons quite apart from the purposes for which it is now used. It had been reported that this compound distributed itself uniformly throughout the fluids of the body, that it was excreted like urea and could be recovered in the urine, completely, unchanged.31 These characteristics, if they could be verified, would make thiour...

The effect of different thiourea (TU) concentrations (10 and 20 mM) on antioxidants, protease activity and protein content with and without H2O2 (50 mM) induced stress was investigated in wheat leaves. A gradual decrease in protein content with a peak at 72 hours was observed in stressed as well as control leaves. This gradual decrease in leaf protein content at different time intervals was com...

The synthesis of a composite material based on graphitic carbon nitride by pyrolytic decomposition at 550 °C mechanical mixture thiourea with the addition aluminum powder in amount 5–30 wt.% has been studied. According to scanning results means electron microscopy, energy dispersive X-ray spectroscopy, and diffractometry synthesized consists nitride, sulfide, residual metallic hydroxide. excess...

Michael addition is one of the most important carbon–carbon bond formation reactions. In this study, an (R, R)-1,2-diphenylethylenediamine (DPEN)-based thiourea organocatalyst was applied to asymmetric nitroalkenes and cycloketones produce a chiral product. The primary amine moiety in DPEN reacts with ketone form enamine activated through hydrogen between nitro group ?, ?-unsaturated nitroalken...

the urgent need of neuraminidase inhibitors (ni) has provided an impetus for understanding the structure requisite at molecular level. our search for selective inhibitors of neuraminidase has led to the identification of pharmacophoric requirements at various positions around acyl thiourea pharmacophore. the main objective of present study is to develop selective ni, with least toxicity and dru...

The purpose of this work is to study the interaction croton fraction with amides – urea and thiourea develop technologies for obtaining accelerators vulcanization rubbers rubber industry.

Thiacalix[4]arene receptors with two thiourea moieties and 2-pyridyl exhibited a heteroditopic dinuclear receptor F ? Ag + ions by positive allosteric effect.

by T ADASHT HrRAKo, National Leprosarium, Tama Zenshoen. The treatment of leprosy has gradually improved since n umerous anti-leprosy d rugs have been introduced not only sulphone compounds such as D.D.S. but also other types of preparations, thiourea derivatives, and antibiotics. Until ETISUL was recently reported to be effective for tuberculosis and also leprosy, there were no effective drugs...