IDH1-mutated intrahepatic cholangiocarcinomas (IDH1-m iCCAs), due to the therapeutic implications with anti-IDH1 drugs. A deeper insight into molecular heterogeneity of this group malignancies is mandatory in order highlight eventual mechanisms resistance. We selected 125 IDH1-m iCCAs treated for resectable, locally advanced or metastatic disease six Italian institutions and one Spanish institu...

Aim Intracorporal knot tying (ICKT) and suturing in minimally invasive surgery (MIS) are key skills for advanced procedures. The best choice an intracorporal slipping technique had not been defined. aim of this study was to compare two techniques: the classical C-loop (Variant I) square-to-slip without changing leadership hand II). Methods A laparoscopic box trainer including laparoscope used I...

background: lifestyle-modification programs including physical activity are essential for both treatment and prevention of type 2 diabetes mellitus ( t2dm ). however, factors associated with physical activity among patients are poorly understood. this study applied social-cognitive theory (sct) for predicting determinants of physical activity among women with t2dm in iran, 2013. methods: in thi...

BACKGROUND Patients with neurodegenerative diseases usually experience significant functional deficits. Older adults with Parkinson's disease (PD) and Alzheimer's disease (AD) may suffer from both motor and cognitive impairments, making them especially vulnerable to poor dual-task performance. OBJECTIVE To analyze the dual-task cost of walking in subjects with PD and AD exposed to motor and c...

Two 21-day feeding trials were conducted using either 24 Hampshire (H) or 24 Chester White (CW) pigs at approximately 5 months of age to evaluate the effects of a diet containing 40% dried whey on the performance and the lactase activities in the gut of finishing pigs. Dried whey increased the incidence and severity of diarrhea in both CW and H (P<.005) but depressed the rate of gain, gain/feed...

Experimental studies have shown that in hypertrophy and heart failure, accumulation of microtubules occurs that impedes sarcomere motion and contributes to decreased ventricular compliance. We tested the hypothesis that these changes are present in the failing human heart and that an entire complex of structural components, including cytoskeletal, linkage, and extracellular proteins, are involv...

lead (pb2+) is a well known neurotoxin that was frequently found in the environment and chronic exposure to lead has been matter of public health. in the present study the effect of lead on spatial memory in developmentally exposed rats and their dams in morris water maze task were investigated. female rats were divided into three groups and two groups exposed to 250 and 750 part per million (p...