نتایج جستجو برای: thrombotic factors
تعداد نتایج: 1089911 فیلتر نتایج به سال:
Diabetes mellitus (DM) is a complex disease characterized by chronic hyperglycemia, a known risk factor for accelerated atherosclerosis and vascular disease. The aim of this study was to show that the connection between DM and other risk factors, such as dyslipidemia, inflammatory phenomena, or the development of certain vascular injuries, leads to a high frequency of thrombotic events in diabe...
INTRODUCTION The identification of the genetic risk factors that could discriminate non- thrombotic from thrombotic antiphospholipid antibodies (aPLA) carriers will improve prognosis of these patients. Several human studies have shown the presence of aPLAs associated with atherosclerotic plaque, which is a known risk factor for thrombosis. Hence, in order to determine the implication of atheros...
Chronic kidney disease (CKD) patients are at high risk for thrombotic events. Indoxyl sulfate (IS) is one of the most potent uremic toxins that accumulates during CKD. Even though IS is associated with an increased risk for cardiovascular disease, its impact on thrombotic events still remains not fully understood. The purpose of the study was to evaluate the direct effect of IS on thrombotic pr...
BACKGROUND Combined oral contraceptives are a common method of contraception, but they carry a risk of venous and arterial thrombosis. We assessed whether use of drospirenone was associated with an increase in thrombotic risk relative to third-generation combined oral contraceptives. METHODS Using computerized records of the largest health care provider in Israel, we identified all women aged...
BACKGROUND Acquired thrombotic thrombocytopenic purpura is still associated with a 10-20% death rate. It has still not been possible to clearly identify early prognostic factors of death. This study involved thrombotic thrombocytopenic purpura patients with acquired severe (<10% of normal activity) ADAMTS13 deficiency and aimed to identify prognostic factors associated with 30-day death. DESI...
OBJECTIVE Thrombosis is an important cause of morbidity and mortality in SLE. We have explored the factors associated with time to the occurrence of thrombotic events in SLE patients to expand our cohort's previous observations. METHOD SLE patients (ACR criteria), age >or=16 years, disease duration <or=5 years at enrollment (T0), African-American, Hispanic (Texan or Puerto Rican) or Caucasian...
Thrombus formation (thrombogenesis) is a process involving platelet adherence to the vessel wall (sometimes at sites of endothelial injury), platelet aggregation and release, thrombin generation and fibrin formation. In addition, it is also well recognized that the process of atherosclerosis is closely related to ongoing formation and organization of mural thrombi [ l , 21. Improved biochemical...
We have developed a photochemical model of thrombotic middle cerebral artery (MCA) occlusion in the guinea pig for investigating factors contributing to the development of cerebral infarction. In this model, cyclic flow reductions (CFRs) after recanalization of the MCA are a common observation and might contribute to the development of cerebral infarction. Therefore, we sought to measure the ti...
The treatment of thrombotic thrombo-cytopenic purpura with exchange transfusions, plasma infusions, and plasma exchange. multicenter survey and retrospective analysis of current efficacy of therapeutic plasma exchange. The thrombotic thrombocytopenic purpura and hemolyt-ic uremic syndromes: evaluation, management, and long-term out-et al. ADAMTS13 activity in thrombotic thrombocytopenic purpura...
Recent advances in basic science have linked some systemic risk factors to endothelial dysfunction which gives rise to atherosclerotic disease and triggers the progression of thrombotic complications. Superficial erosion of the stenotic plaque can be observed in one-third of acute coronary syndromes (ACS). In these cases the presence of classic risk factors such as diabetes mellitus, hyperchole...
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