Objective: The in-vivo study was carried out to explore the possible protective effect of thymoquinone on chlorpromazine induced catalepsy and locomotor activity in rats. Materials and Methods: Twenty four rats were used for this study and were divided into four groups, each group containing six animals. The animals were evaluated after repeated administration of chlorpromazine (CPZ) 30 minutes...

Nigella sativa L. and its active component, thymoquinone, attract a lot of scientific attention. However, very few review articles on this issue have been published so far, no relied the method bibliometrics, which is currently most prominent technique for citation mapping. 
 This involves total 2072 studies thymoquinone reported in Scopus database between 1915 September 15, 2022. The data...

The objective of this study was to compare the oil extraction yield and essential oil composition of Indian and Iranian Nigella sativa L. extracted by using Supercritical Fluid Extraction (SFE) and solvent extraction methods. In this study, a gas chromatography equipped with a mass spectrophotometer detector was employed for qualitative analysis of the essential oil composition of Indian and Ir...

Maize is one the most important staple foods in the world. However, numerous pests, such as fungal pathogens, e.g., Fusarium verticillioides, and insects, such as Sitophlilus zeamais, attack maize grains during storage. Many F. verticillioides strains produce fumonisins, one of the most important mycotoxin that causes toxic effects on human and animal health. This situation is aggravated by the...

Nigella sativa Linn. (N. sativa) and its bioactive constituent Thymoquinone (TQ) have demonstrated numerous pharmacological attributes. In the present study, the neuroprotective properties of Thymoquinone-rich fraction (TQRF) and TQ against hydrogen peroxide- (H2O2-) induced neurotoxicity in differentiated human SH-SY5Y cells were investigated. TQRF was extracted using supercritical fluid extra...

The present study was undertaken to evaluate the possible protective effect of thymoquinone on chlorpromazine induced catalepsy, locomotor activity and cerebral oxidative stress in rats. The rats were divided into four groups, each group containing eight animals. The animals were evaluated after repeated administration of chlorpromazine (CPZ) 30 min before the administration of thymoquinone (TQ...

Nigella sativa (Family Ranunculaceae) is a widely used medicinal plant throughout the world. N. sativa is referred in the Middle East as a part of an overall holistic approach to health. Pharmacological properties of N. sativa including immune stimulant, hypotensive, anti-inflammatory, anti-cancer, antioxidant, hypoglycemic, spasmolytic and bronchodilator have been shown. Reactive oxygen specie...

Abstract: Radiation and chemicals were the major clinical toxicants known to cause cellular damage during prognostic interventions in vivo. Cellular molecular damages liver causes for hepatocellular injury due various toxicities. Though many antioxidants alleviate types of hepatotoxicities, protection exerted by combination N-acetyl cysteine (NA) Thymoquinone (TQ) combined toxicities radiation ...

Objective: Several phytochemical agents have been known to exhibit a neuroprotective effect. Among them, curcumin, linalool, rutin, safranal, and thymoquinonewere widely investigated and neuroprotective activity of each of them was shown by several studies. This work was planned to investigate whether different combinations of them could induce better neuroprotective effect against glucose/seru...

Medicinal plants gained momentous support in the recent era for their therapeutic potential. The core objective of the research study was to characterize the indigenous variety of black cumin (Nigella sativa L.), locally known as “Kalonji” and its fixed and essential oils. Compositional analysis revealed that it contains appreciable quantities of carbohydrates, proteins and fats. Moreover, pota...