INTRODUCTION Hyperthyroidism is a syndrome caused by the excessive production and secretion of the thyroid hormones T3 and T4 by an autonomous thyroid gland. Feline hyperthyroidism was first reported in 1979 and since then it has become a common disease in cats. Histopathology of affected thyroids usually reveals thyroid hyperplasia or benign thyroid adenoma, however in a small percentage of ca...

Pituitary tumor transforming gene (PTTG)-binding factor (PBF or PTTG1IP) is a little characterized protooncogene that has been implicated in the etiology of breast and thyroid tumors. In this study, we created a murine transgenic model to target PBF expression to the thyroid gland (PBF-Tg mice) and found that these mice exhibited normal thyroid function, but a striking enlargement of the thyroi...

The most significant impact of the Chernobyl accident is the increased incidence of thyroid cancer among children who were exposed to short-lived radioiodines and 131-iodine. In order to accurately estimate the radiation dose provided by these radioiodines, it is necessary to know where iodine is incorporated. To do that, the distribution at the cellular level of newly organified iodine in the ...

BACKGROUND Increased oxidative stress has been suggested as one of the underlying mechanisms in iodide excess-induced thyroid disease. Metallothioneins (MTs) are regarded as scavengers of reactive oxygen species (ROS) in oxidative stress. Our aim is to investigate the effects of propylthiouracil (PTU), a thyroid peroxidase inhibitor, perchlorate (KClO₄), a competitive inhibitor of iodide transp...

Many previous studies including ours have reported that athyreotic patients on levothyroxine (LT4) relatively low serum free triiodothyronine (FT3) levels, whereas with large goitrous diseases often high FT3 levels. Here we investigated Hashimoto thyroiditis (HT) LT4 to study the relationship between thyroid volume (TV) and hormone status in hypothyroid LT4. We retrospectively studied 408 euthy...

The induction of tumors of the adenohypophysis in mice by radiothyroidectomy (Gorbman [8]) has been amply confirmed. These tumors are thyrotropic (4). They are initially transplantable only to hosts whose thyroid function has been depressed by either radiothyroidectomy or surgical thyroidectomy; but autonomous strains have been developed after subpassages of most of the originally dependent lin...

BACKGROUND Thyroid hormone has the a major role in the cardiovascular system function and cardiac a As well as to maintain the cardiovascular homeostasis A slightly change ind thyroid status actually affects cardiovascular mortality hemodynamic. The background of this study was to define the prevalence of thyroid dysfunction in acute coronary syndrome (ACS). OBJECTIVES The primary objective w...

Bullfrog (Rana catesbeiana) tadpoles are of value to amphibian researchers because of their large size, and year-round availability due to overwintering in many latitudes. Concern over a possible difference in hormonal parameters in tadpoles obtained at different times of the year prompted us to investigate thyroid gland secretion in vitro, plasma and ocular melatonin, and plasma corticosteroid...

This paper describes an attempt to measure in vitro iron uptake from serum by human thyroid slices and to relate the uptake to tissue iron stores, folic acid status, and tissue viability. It is an extension of work previously reported (Buchanan, 1969). Thyroids were obtained from patients undergoing partial thyroidectomy for colloid goitre and serum from clinically normal healthy adults. The ha...