The mean pressure drop across the mitral valve and atrioventricular pressure half-time were measured noninvasively by Doppler ultrasound in 40 normal subjects, in 17 patients with mitral regurgitation, 32 patients with mitral stenosis and 12 with combined stenosis and regurgitation. In normal subjects pressure half-times were 20--60 msec, in patients with isolated mitral regurgitation 35--80 ms...

Large-Eddy simulation (LES) is performed to study pulsatile blood flow through a 3D model of arterial stenosis. The model is chosen as a simple channel with a biological type stenosis formed on the top wall. A sinusoidal non-additive type pulsation is assumed at the inlet of the model to generate time dependent oscillating flow in the channel and the Reynolds number of 1200, based on the channe...

BACKGROUND Hemodynamic tandem intracranial lesions (TILs) on intracranial magnetic resonance angiography, which develop flow dependently, have been overlooked clinically in patients undergoing carotid endarterectomy. As they represent severe baseline hemodynamic compromise at the segment, they may be associated with distinctive clinical outcomes. METHODS AND RESULTS We assessed 304 consecutiv...

Background: Meatal stenosis is of common late complication of neonatal circumcision, albeit the appropriate post-operative care and conventional consumption of topical agents such as tetracycline. Nevertheless, its underlying etiology still remained vague. Lack of protective effects of foreskin and subsequent inflammation reaction due to chemical and mechanical irritation is thought to be the m...

Background Coronary thrombosis is a dynamic process dependent on the pathological substrate, the local shear forces, and blood factors. Methods and Results We investigated the effect of a severe (80%) eccentric stenosis on fibrin(ogen) interaction with a deeply damaged vessel wall, its relation to platelet deposition in thrombus formation, and the influence of time on thrombus growth. Porcine '...

background: the incidence of stroke after coronary artery bypass grafting (cabg) is between 0.9% and 6.7%, which significantly increases in-hospital and out-hospital costs. this study was designed to evaluate the prevalence of significant carotid stenosis and its risk factors in cabg. methods: in total, 2044 consecutive patients undergoing elective cabg were investigated through a pre-operative...

The aim of this paper is to study the effect of slip velocity and shape of stenosis on non-Newtonian flow of blood through a stenosed arterial segment. Blood is modeled as Bingham-Plastic fluid in a uniform circular tube with a radially non-symmetric stenosis. The problem is investigated by a joint effort of analytical and numerical techniques. The influence of stenosis shape parameter, slip ve...