UNLABELLED The development of a PET radioligand selective for I2-imidazoline binding sites (I2BS) would enable, for the first time, specific, measurable in vivo imaging of this target protein, along with assessment of alterations in expression patterns of this protein in disease pathophysiology. METHODS BU99008 was identified as the most promising I2BS radioligand candidate and radiolabeled w...

Cet article aborde la façon dont les intervenants sociaux auprès des enfants de rue au Sénégal mobilisent deux univers normatifs dans le cadre leur intervention. Ces acteurs se réfèrent d’une part à Convention internationale relative aux droits l’enfant et d’autre ce que nous désignons comme une « morale du sens commun &#1...

Brain tumour is a severe disease that may lead to death if unrecognized and untreated. tumor identification segmentation complex task in medical image processing. For radiologists, diagnosing classifying from various images challenging process. When the data size large, deep learning methods outperform conventional algorithms. Convolutional Neural Networks are found be one of popular architectu...

A flexible carbon fiber aerogel with a very high surface area for supercapacitor application is reported by carbonization and chemical activation of low-cost natural cotton with KOH. The carbon fibers in the aerogel present as a twisted and tubular structure. Depending on the amount of KOH used in the activation process, the specific surface area of aerogels ranges from 1536 to 2436 m g−1, whil...

In this work, we present the late-time behaviour of universe in context Einstein–Gauss–Bonnet gravitational theory. The theory involves a scalar field, which represents low-effective quantum corrections, assisted by function [Formula: see text] solely depending from Gauss–Bonnet topological invariant text]. It is considered that dark energy serves as impact all geometric terms, are included act...

Broomrapes (Orobanche spp.) are parasitic weeds and considered as a major limiting factor for the cultivation of various crops in many parts of the world. Due to the special biology of broomrape, including seed production, dispersal and longevity, the control of these species are often extremely difficult. Broomrape poses a serious threat to Iran’s agriculture; therefore exploring potential bio...

Approximately 85% of lung cancers are non–small-cell lung cancers (NSCLCs), which are often diagnosed at an advanced stage and associated with poor prognosis. Currently, there are very few therapies available for NSCLCs due to the recalcitrant nature of this cancer. Mutations that activate the small GTPase KRAS are found in 20% to 30% of NSCLCs. Here, we report that inhibition of superoxide dis...

In the present study, we explored the participation of Notch1 targeted regulation of mir-224/LRIG2 gene signal pathway in proliferation and apoptosis of cervical cancer cells. Forty-nine cases of cervical cancer lesion samples from cervical cancer patients treated in our hospital from February 2013 to February 2015 were chosen as subjects (the observation group), and cervical samples of healthy...

Bcl-2 and other anti-apoptotic proteins are associated with defective caspase-dependent apoptotic pathways, resulting in chemoresistance. We have previously shown that ATN-224, a copper chelator drug, induces cell death in murine thymic lymphoma cells transfected with Bcl-2. In the current study, we tested whether ATN-224 was effective in diffuse large B cell lymphoma (DLBCL) cells, which have ...