Eukaryotic cyclic nucleotide-modulated (CNM) ion channels perform various physiological roles by opening in response to cyclic nucleotides binding to a specialized cyclic nucleotide-binding domain. Despite progress in structure-function analysis, the conformational rearrangements underlying the gating of these channels are still unknown. Here, we image ligand-induced conformational changes in s...

During stereotactic body radiotherapy, high radiation dose (~60 Gy) is delivered to the tumour in small fractionation regime. In this study, the dosimetric characteristics were studied using radiochromic film during respiratory-gated and non-gated lung stereotactic body radiotherapy (SBRT). Specifically, the effect of respiratory cycle and amplitude, as well as gating window on the dosimetry we...

INTRODUCTION Free-breathing cardiac cine imaging with respiratory and cardiac self-gating provides flexibility and convenience for patient scans. Here we propose a 3D radial cardiac cine imaging technique that improves upon self-gating by adding 3D respiratory motion correction. The 3D respiratory motion signals are derived from multiple projections through the data used for image reconstructio...

Fast inactivating Shaker H4 potassium channels and nonconducting pore mutant Shaker H4 W434F channels have been used to correlate the installation and recovery of the fast inactivation of ionic current with changes in the kinetics of gating current known as "charge immobilization" (Armstrong, C.M., and F. Bezanilla. 1977. J. Gen. Physiol. 70:567-590.). Shaker H4 W434F gating currents are very s...

Models of decision making differ in how they treat early evidence as it recedes in time. Standard models, such as the drift diffusion model, assume that evidence is gradually accumulated until it reaches a boundary and a decision is initiated. One recent model, the urgency gating model, has proposed that decision making does not require the accumulation of evidence at all. Instead, accumulation...

Power gating has emerged as a promising technique for reduction of leakage current in sub-100nm CMOS circuits. To identify power gating opportunities within a system, logic circuits must be characterized for design overheads they present when power gating structures are inserted. In this paper, models are developed to quantify two mode transition overheads: wakeup time and wakeup energy using b...

BACKGROUND Numerous studies have demonstrated sensory gating deficits in schizophrenia. However, only a few longitudinal studies report on the effects of antipsychotic treatment on sensory gating deficits and their results are inconsistent. In the present study, P50 suppression and its neural generators were investigated in antipsychotic-naïve first-episode patients with schizophrenia before an...

Background Sensitive hearing in Drosophila requires the NOMPC (TRPN1) channel. is a bona fide mechano-electrical transduction (MET) channel whose amino-terminal ankyrin repeat (AR) domain consists of 29 ARs. These ARs assemble into helical structure, tether intracellularly to microtubules, and are essential for mechano-gating. Because these findings it was hypothesized that AR might function as...