timp2

Sarah L McLaughlin Ryan J Ice Anuradha Rajulapati Polina Y Kozyulina Ryan H Livengood Varvara K Kozyreva Yuriy V Loskutov Mark V Culp Scott A Weed Alexey V Ivanov Elena N Pugacheva

UNLABELLED The scaffolding protein NEDD9 is an established prometastatic marker in several cancers. Nevertheless, the molecular mechanisms of NEDD9-driven metastasis in cancers remain ill-defined. Here, using a comprehensive breast cancer tissue microarray, it was shown that increased levels of NEDD9 protein significantly correlated with the transition from carcinoma in situ to invasive carcino...

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TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients

2015

Esther L. Ashworth Briggs Tze’Yo Toh Rajaraman Eri Alex W. Hewitt Anthony L. Cook

PURPOSE Elevated intraocular pressure (IOP) is the only known modifiable risk factor for primary open angle glaucoma (POAG), and it can be caused by reduced aqueous humor outflow from the anterior chamber. Outflow is predominantly regulated by the trabecular meshwork, consisting of specialized cells within a complex extracellular matrix (ECM). An imbalance between ECM-degrading matrix metallopr...

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In vitro anti-angiogenic effects of cryo-preserved amniotic membrane and the role of TIMP2 and thrombospondin

Bovine endometrial metallopeptidases MMP14 and MMP2 and the metallopeptidase inhibitor TIMP2 participate in maternal preparation of pregnancy

Relationship of common variants in MPP7, TIMP2 and CASP8 genes with the risk of chronic achilles tendinopathy

MiR-761 Promotes Progression and Metastasis of Non-Small Cell Lung Cancer by Targeting ING4 and TIMP2

MicroRNA-15b promotes proliferation and invasion of non-small cell lung carcinoma cells by directly targeting TIMP2

NEDD9 depletion leads to MMP14 inactivation by TIMP2 and prevents invasion and metastasis.

TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients

Routine Adoption of TIMP2 and IGFBP7 Biomarkers in Cardiac Surgery for Early Identification of Acute Kidney Injury

An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy

MicroRNA‑130a regulated by HPV18 E6 promotes proliferation and invasion of cervical cancer cells by targeting TIMP2