Address correspondence to Barry M. Gumbiner, Memorial Sloan-Kettering Cancer Center, Box 564, 1275 York Avenue, New York, NY 10021. E-mail: [email protected] Adhesive interactions between cells are dynamic and regulated during tissue development and homeostasis. Cadherins are major cell–cell adhesion molecules involved in the development and maintenance of all solid tissues (Takeichi, 19...

BACKGROUND Unique adhesive and biocompatibility properties of mussel adhesive proteins (MAPs) are known for their great potential in many tissue engineering and biomedical applications. Previously, it was successfully demonstrated that redesigned hybrid type MAP, fp-151, mass-produced in Gram-negative bacterium Escherichia coli, could be utilized as a promising adhesive biomaterial. However, pu...

OBJECTIVE This study was undertaken to test injectable surgical sealants that are biocompatible with fetal membranes and that are to be used eventually for the closure of iatrogenic membrane defects. STUDY DESIGN Dermabond (Ethicon Inc, Norderstedt, Germany), Histoacryl (B. Braun GmbH, Tuttlingen, Germany), and Tissucol (Baxter AG, Volketwil, Switzerland) fibrin glue, and 3 types of in situ f...

OBJECTIVES We evaluated mRNA expression levels of genes that encode TGF-β1; the TGF-β1 receptor; the collagen-modifying enzymes LOX, PLOD1, and PLOD2; and the extracellular matrix proteins COMP, FN1, TNC and TNXB in synovial/capsule specimens from patients with idiopathic adhesive capsulitis. Possible associations between the measured mRNA levels and clinical parameters were also investigated. ...

Background: Pilonidal disease is a common chronic disorder mainly seen in the sacrococcygeal region, especially in young males. Different surgical methods have been described for the treatment. However, none of the methods has emerged as being superior to the others. An ideal treatment should be simple, lead to minimal disability, and have a rapid return to normal activity. We present the preli...

Purpose To determine whether a fibrin adhesive can facilitate the performance of sutureless lamellar keratoplasty and attachment of amnion to bare sclera.

PURPOSE To evaluate axonal regeneration after end-to-side nerve repair with fibrin glue in rats. METHODS Forty-five Wistar rats were divided into three groups: group A (n=15), were not submitted to surgery (control group); group B (n=15) were submitted to fibular transection without repair; and group C (n=15), were submitted to fibular transection with end-to-side nerve anastomosis using fibr...

CONTEXT Treatment of pancreatic fistulae after pancreaticoduodenectomy is extremely important because it determines the patient's postoperative course. In particular, treatment of grade B cases should be conducted in a timely manner to avoid deterioration to grade C. OBJECTIVE We report the successful treatment of six cases of postoperative intractable, grade B pancreatic fistulae, in which f...

BACKGROUND Surgical intervention for corneal perforation is indicated when the anterior chamber does not reform within a short period of time. Herein, we report the successful management of a small paracentral corneal perforation using autologous iris incarceration and tissue adhesive. CASE A 41-year-old man developed a small paracentral corneal perforation (0.5 mm in size) in the right eye, ...

INTRODUCTION: A major challenge in engineering cartilage repair is the integration of the tissue-engineered construct (TEC) with the adjacent native cartilage. Low cellularity of cartilage, low mobility of chondrocytes and the fact that native chondrocytes at the edge of the defect may be damaged contribute to decreased graft integration with the host tissue. Adhesives such as fibrin are freque...