PURPOSE To enhance the immunogenicity of the model subunit vaccine, ovalbumin (OVA) was combined with platycodin (PD), a saponin adjuvant. To reduce the toxicity of PD, OVA, and adjuvant were loaded together into liposomes before being incorporated into a dissolving microneedle array. METHODS OVA- and PD-loaded liposomes (OVA-PD-Lipos) were prepared using the film dispersion method. Their upt...

Fast dissolving drug delivery is the new approach to administer drugs; mouth dissolving film is one of them. The object of the present research work was to formulate a mouth dissolving film of Zolpidem tartrate from polymers Hydroxypropyl cellulose (EF-P) with a combination of Hydroxypropyl methyl cellulose K-15 by solvent casting method for enhancing the drug release rate and absorption to inc...

In order to screen the strains with Potassium and phosphorus-releasing bacteria from soil, potassium-dissolving medium was used for preliminary screening, transparent circle method re-screening. The content of soluble potassium determined by sodium tetraphenylborate method, phosphorus anticolorimetric molybdenum antimony. were identified morphological, biochemical molecular biology. results sho...

Hydrogen peroxide is an environmentally friendly bleaching chemical that widely used in alkaline media the pulp and paper industry. In this study, unconventional reaction conditions of conventional P-stage were performed to evaluate its effect on cellulose. The objective was “tailor” cellulose degradation according different applications, such as dissolving pulps. Different operating studied: p...

the purpose of these case reports is to analyze the results of gingivectomy and gingival troughing to determine the evidence on the effectiveness of laser-assisted soft tissue procedures and soft tissue management in aesthetic dentistry.the patients in these case reports underwent 980 nm diode laser assisted gingivectomy and gingival troughing to achieve immediate hemostasis and moisture contro...

Poly(propylene fumarate) (PPF) is an injectable, biodegradable polymer that has been used for fabricating preformed scaffolds in tissue engineering applications because of in situ crosslinking characteristics. Aiming for understanding the effects of pore structure parameters on bone tissue ingrowth, 3-dimensional (3D) PPF scaffolds with controlled pore architecture have been produced in this st...

The objective of this paper was to review the information about mouth dissolvi improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market b and contributing to extension of patent life. MDDDS have the unique property of rapi...

The clinical impact of biotechnology has been constrained by the limitations of traditional hypodermic injection of biopharmaceuticals. Microneedle patches have been proposed as a minimally invasive alternative. In this study, the translation of a dissolving microneedle patch designed for simple, painless self-administration of biopharmacetucials that generates no sharp biohazardous waste is as...

This study was concerned with the investigation of acute pharmacological responses (pharmacodynamics) including analgesic and anti-inflammatory effects of ketorolac tromethamine fast dissolving tablets prepared by direct compression method using 3% croscarmellose sodium as a superdisintegrant by applying tail flick test and carragenan induced rat paw edema test respectively. Also, the work aime...