The passage of a vascular-injected paramagnetic contrast reagent (CR) bolus through a region-of-interest affects tissue (1)H(2)O relaxation and thus MR image intensity. For longitudinal relaxation [R(1) identical with (T(1))(-1)], the CR must have transient molecular interactions with water. Because the CR and water molecules are never uniformly distributed in the histological-scale tissue comp...

bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. recently, various stem cells, including embryonic stem cells (escs), bone marrow-derived mesenchymal stem cells (bm-mscs), umbilical cord blood-derived mesenchymal stem cells (ucb-mscs), adipose tissue-derived stem cells (adscs), muscle-derived stem cell...

background and aims. furcally-involved teeth present unique challenges to the success of periodontal therapy and influence treatment outcomes. this study aimed to assess to compare use of adm and connective tissue membrane in class ii furcation defect regeneration. materials and methods. 10 patient with 2 bilaterally class ii furcation defects in first and/or second maxilla or man-dibular molar...

lipoma is the most common soft tissue tumor but the presence of osseous component within the tumor is quite rare. some studies show that less than 1% of lipomas were ossified. we describe the histological, radiological and diagnostic features of an ossified intramuscular lipoma. to the best of the authors' knowledge, a symptomatic ossified intramuscular lipoma without any cortical erosion and h...

A fundamental reworking of pharmacokinetic theory for the use of contrast reagents (CRs) in T(1)-weighted MRI studies is presented. Unlike the standard model in common use, this derivation starts with the quantities measured, the intravascular, interstitial, and intracellular (1)H(2)O signals. The time dependences of CR concentrations are introduced as perturbations of the T(1) values of these....

Introduction Diffusion MRI using pulsed gradient spin echoes (PGSE) is known to yield information about tissue microstructure; for instance, measurements with different diffusion times (TD) provide structural information regarding cellular size distributions [1]. Recent studies have shown that exchange may affect PGSE measurements in white matter [2] and in sub-acute stroke lesions [3]. However...

A two-dimensional multiscale gas exchange model was developed to evaluate the effect of ambient conditions, fruit size, and maturity on intracellular O(2) and CO(2) concentrations in pear fruit via computational analysis. The model consists of interconnected submodels that describe the gas exchange at the macroscopic scale of the fruit and the microscopic scale of the cells. The multiscale mode...

Physiologists have devised many models for interpreting water and solute exchange data in whole organs, but the models have typically neglected key aspects of the underlying physiology to present the simplest possible model for a given experimental situation. We have developed a physiologically realistic model of microcirculatory water and solute exchange and applied it to diverse observations ...

CONTEXT Tissue microarray (TMA) is an array-based technology allowing the examination of hundreds of tissue samples on a single slide. To handle, exchange, and disseminate TMA data, we need standard representations of the methods used, of the data generated, and of the clinical and histopathologic information related to TMA data analysis. OBJECTIVE To create a comprehensive data model with fl...

OBJECTIVE To review the status of haemoglobin-oxygen affinity in critical illness and investigate the potential to improve gas exchange, tissue oxygenation and outcome by manipulations of the oxyhaemoglobin dissociation curve. DATA SOURCES Articles and published peer-review abstracts. SUMMARY OF REVIEW The P50 of a species is determined by natural selection according to animal size, tissue ...