We herein describe the case of a 68-year-old man who developed overt diabetes mellitus following the topical administration of dexamethasone 0.1%-containing ointment over a five-month period to treat oral lichen planus. The topical dexamethasone therapy was discontinued gradually, and the patient was subsequently treated with insulin for one month without clinical signs of overt adrenal insuffi...

Topical corticosteroids have been the cornerstone of treatment over last six decades for various dermatoses characterized by dry, scaly, crusted, or erythematous skin as well those associated with inflammation and pruritus. The potency a topical steroid depends on specific molecule, amount drug reaching target, absorption through (0.25%–3%), formulation. Clobetasol propionate (CP) 0.025% cream ...

Welfare attention on surgical husbandry practices for farm animals focuses on the fact that many of the procedures involve innervated tissues and are traditionally performed without anaesthesia or analgesia. There are several approaches available for addressing welfare concerns surrounding these procedures. These options include 1) cessation of the procedure in combination with altered manageme...

BACKGROUND Placebo effects on pain have been found to vary in size for different routes of medication administration (e.g. oral vs. injection). This has important implications for both clinical research and practice. To enhance our understanding of these differential placebo effects, research on the underlying expectations about multiple routes and symptoms other than pain is vital. METHODS A...

A randomised, double blind, single dose study of topical haloperidol, a dopamine receptor blocking drug, was performed on 20 healthy volunteers. After its administration a modest reduction in intraocular pressure was recorded over the six-hour study period, but the difference was not significant at the p less than 0.05 level. Although dopamine blocking agents are effective in reducing intraocul...

© 2005 CMA Media Inc. or its licensors Reason for posting: Many patients with eczema, or atopic dermatitis, are prescribed the topical immunomodulators tacrolimus and pimecrolimus. The drugs are often given to people for whom the potential side effects of topical corticosteroids (e.g., systemic absorption, skin thinning, telangiectasia) are a concern. However, the US Food and Drug Administratio...

Topical applications of the drugs have an advantage delivering drug directly to site action and acting for a longer period time. Skin is one most widespread readily accessible organs on human body topical administration main route delivery system. The aim this project was formulate natural safe herbal skin toner which has calming, soothing, astringent, effect face reduce facial irritancy enhanc...

22 23 24 Combined systemic and topical administration of voriconazole have been successfully used to 25 treat keratomycosis infection. No voriconazole eye drop product being commercially 26 available, we prepared a sterile eye drop solution (10 mg/ml). Voriconazole remains stable 27 over 30 days providing an eye drop solution suitable for topical treatment of fungal keratitis. 28 29 30 31 32 33...

Post-inflammatory hyperpigmentation is common problem, but its treatment still remains challenging. Tranexamic acid has been used to treat or prevent excessive bleeding loss in various medical conditions. There have been some reports of the effect of oral and topical tranexamic acid for treatment of pigmented disorder. Herein we report on a case of female patient who showed improvement of PIH a...

trans-Methyl styryl ketone (MSK; trans-4-phenyl-3-buten-2-one) is a beta-unsaturated ketone that has a wide range of uses in industry and is present in numerous consumer products. Although MSK has been shown to be positive in several in vitro mutagenic assays, it does not seem to be overtly toxic in animal models. This lack of toxicity may relate to its poor absorption and/or rapid elimination....