Cubosomes are the nanoparticles of bicontinuous, lyotropic cubic phases, comprised curved lipid bilayers organized into a three-dimensional honeycomb (cavernous) like structures separating two internal aqueous channels and large interfacial area. Cubic phases optically isotropic, very viscous, solid-like (crystalline) with crystallographic symmetry. They can encapsulate hydrophilic, hydrophobic...

INTRODUCTION A water-in-oil microemulsion is a thermodynamically stable emulsion that has the capacity to 'hide' water-soluble molecules within a continuous oil phase. The very small size of the water droplets within the microemulsion means that these types of formulation can be applied topically to the skin, with the result that peptides and proteins can be delivered effectively into the derma...