1 Department of Pathology and Laboratory Medicine, Santa Clara Valley Medical Center, San Jose, CA. * Address correspondence to this author at: Santa Clara Valley Medical Center, Department of Pathology and Laboratory Medicine, 751 S. Bascom Ave, San Jose, CA 95128. E-mail [email protected]. Received October 1, 2014; accepted December 11, 2014. DOI: 10.1373/clinchem.2014.234229 © ...

How can synapses change the amount of neurotransmitter released during synaptic plasticity? Although release in general is intensely investigated, its determinants during plasticity are still poorly understood. As a model for plastic strengthening of synaptic release, we here use the well-established presynaptic homeostatic compensation during interference with postsynaptic glutamate receptors ...

Alborz Mountains is a region of active deformation within Arabia-Eurasia collision zone. The study fault system in western Alborz comprises abundant evidence of active faulting accompanied by occurrence of historical earthquakes. Active tectonics of Manjil-Rudbar fault zone whose movement caused destructive 1990 Manjil-Rudbar earthquake was concentrated in this article through geomorphic and st...

The prevalence of Indonesian smokers is increasing, the age getting younger every day, and number cigarettes consumed increasing. Smoking behavior or habits can have an impact on emergence pulmonary ventilation disorders due to irritation excessive mucus secretion in bronchi. study aimed determine correlation between age, cigarettes, duration smoking with vital capacity value lungs active smoke...

background: fat-rich diet may alter oocyte development and maturation and embryonic development by inducing oxidative stress (os) in follicular environment. objective: to investigate the relationship between fat intake and oxidative stress with oocyte competence and embryo quality. materials and methods: in observational study follicular fluid was collected from 236 women undergoing assisted re...

Neurotransmitter release at chemical synapses occurs when synaptic vesicles fuse to the presynaptic membrane at a specialized site termed the active zone. The depolarization-induced fusion is highly dependent on calcium ions, and, correspondingly, the transmission characteristics of synapses are thought to be influenced by the spatial arrangement of voltage-gated calcium channels with respect t...

Osteoclasts resorb bone through the formation of a unique attachment structure called the sealing zone. In this study, a role for thyroid hormone receptor-interacting protein 6 (TRIP6) in sealing zone formation and osteoclast activity was examined. TRIP6 was shown to reside in the sealing zone through its association with tropomyosin 4, an actin-binding protein that regulates sealing dimensions...

Active zone proteins cluster synaptic vesicles at presynaptic terminals and coordinate their release. In forward genetic screens, we isolated a novel Caenorhabditis elegans active zone gene, clarinet (cla-1). cla-1 mutants exhibit defects in synaptic vesicle clustering, active zone structure and synapse number. As a result, they have reduced spontaneous vesicle release and increased synaptic de...