Galega officinalis, goat′s rue, a plant native to Euro-Asia and North Africa was introducing to Egypt as an objective for introducing important medicinal plants. The plant claimed to be useful in diabetic treatment, reduce weight and as anti platelet aggregation. Plant density and different nitrogen sources (organic, bio and chemical fertilizers) were tried to evaluate their effect on growth, y...

The metabolism in vitro of pyrrolizidine alkaloids by microsomes from eight animal species was studied. The rates of pyrrole production ranged from high to low in the following order: male hamster > male rabbit > male mouse > male rat > beef steer > beef bull female rat > wether lamb > male chicken male Japanese quail. With the exception of the rabbit and chicken, there appeared to be a direct ...

Alkaloids are the main active ingredients in the medicinal plant Dendrobium officinale. Based on the published genomic and transcriptomic data, a proposed terpenoid indole alkaloid (TIA) biosynthesis pathway may be present in D. officinale. In this study, protocorm-like bodies (PLBs) with a high-yielding production of alkaloids were obtained by the optimization of tryptophan, secologanin and me...

Many medicinal plants were with a long history of use in folk medicine against a variety of diseases. Recently, many researchers have taken a great interest on medicinal plants for their phytochemical constituents and biological activities including antioxidant activity. The present study was aimed to evaluate phytochemical analysis, quantification of total phenolic, alkaloid contents and antio...

The objective of the study was to investigate the effect of exogenous nitric oxide on cellular response and production of secondary metabolites in Catharanthus roseus callus. The Cell suspension and callus of C. roseus were treated with sodium nitroprusside, then cell viability, morphology, the amount of H2O2, proline, lipid peroxidation, the activity of superoxide dismutase, catalase and perox...

Different classes of known alkaloid compounds were identified for the first time in leaves and barks of Ficus benjamina L. from Moraceae family. The identification of 28 alkaloids in F. benjamina leaves and 14 alkaloids in its barks was identified using chromatographic analysis as Gas Chromatography associated to Mass Spectrometry (GC-MS). This characterization analysis allows to verifying the ...

We studied the effect of the plant alkaloid castanospermine on the biosynthesis and secretion of human hepatoma glycoproteins. The HepG-2 cells, grown in the presence or absence of the alkaloid, were labelled with [2-3H]mannose and then the labelled glycopeptides were prepared by Pronase digestion. This material was analysed by gel filtration on Bio-Gel P-4 before and after treatment with endo-...

A total of 232 alkaloids, representing 21 structural classes were detected in skin extracts from the dendrobatid poison frog Oophaga pumilio, collected from 53 different populations from over 30 years of research. The highly toxic pumiliotoxins and allopumiliotoxins, along with 5,8-disubstitiuted and 5,6,8-trisubstituted indolizidines, all of which are proposed to be of dietary mite origin, wer...

Spatial heterogeneity in the strength or agents of selection can lead to geographic variation in ecologically important phenotypes. Many dendrobatid frogs sequester alkaloid toxins from their diets and often exhibit fixed mutations at NaV1.4, a voltage-gated sodium ion channel associated with alkaloid toxin resistance. Yet previous studies have noted an absence of resistance mutations in indivi...